2. Articole
Permanent URI for this collectionhttps://msuir.usm.md/handle/123456789/46
Browse
848 results
Search Results
Item Produs educațional prezentat la proba practică în procesul de atestare a cadrelor didactice(CEP USM, 2024) Goraș, Mariana; Dîru, Mariana; Tachi, Natalia; Chiosa, ZinaidaÎn articol este prezentat un exemplu de produs educațional, prevăzut pentru proba practică în Regulamentul de atestare a cadrelor didactice din învățământul general, profesional tehnic și din cadrul structurilor de asistență psihopedagogică, aprobat prin ordinul Ministrului Educației, Culturii și Cercetării nr. 1091 din 07.10.2020, cu modificările ulterioare, aprobate prin ordinul Ministrului Educației și Cercetării nr. 1335 din 30.09.2024 (publicat în Monitorul Oficial al Republicii Moldova nr. 437-439, art. 814, la 18.10.2024) [1]. În calitate de produs din practica educațională propunem - Ghidul de implementare a curriculumului la disciplina opțională STEM în Criminalistică. Sunt descrise etapele de elaborare ale produsului educațional, precum și elementele de structură: 1) Argument/ Descrierea problemei și motivarea necesității schimbării; 2) Scop și obiective SMART; 3) Planul de acțiuni implementat (Ce? Când? Cum? Responsabil, resurse); 4) Rezultate cantitative și calitative obținute/impactul practicii educaționale de succes; 5) Asigurarea durabilității schimbărilor inițiate; 6) Diseminarea rezultatelor prin prezentări, publicații, formări la nivel de instituție/ raion/ municipiu/ republică.Item Influența condițiilor de procesare asupra conținutului de antioxidanți în fructus Rosae(CEP USM, 2024) Grigoraș, Carolina; Blonschi, Vladislav; Duca, Gheorghe; Nica, SimonaFructele de măceș sau Fructus Rosae este un produs vegetal medicinal bogat în vitamine (A, B, C, D și E), minerale (Ca, Fe, K, Mg, Mn, S, Si și Se), polifenoli și are capacitate antioxidantă înaltă. Cel mai mare dezavantaj însă al vitaminei C, extrasă din produsele vegetale, este că aceasta se descompune ușor sub influența oxigenului, a condițiilor de procesare și păstrare din cauza fermentului ascorbinaza. A fost determinat regimul optim de temperatură și forma fructelor de măceș pentru a menține un conținut înalt de vitamina C și alți antioxidanți, responsabili de activitatea biologică a produsului vegetal medicinal. S-a stabilit că regimul optim de temperatură necesar dezactivării ascorbinazei este de 60°C timp de 30 minute, de asemenea forma produsului integral sau pulbere nu afectează esențial activitatea antioxidantă demonstrată prin metoda ABTS a ambelor forme.Item Synthesis of new bis-thiosemicarbazones based on 2,2’-[propane-1,3-diil-bis-(oxi)]dibenzaldehyde with biological potential(CEP USM, 2024) Ciursin, Andrei; Rusnac, Roman; Gulea, AurelianCancer is the second most common cause of death. No known drug meets 100% the needs of the medical industry. For these reasons, many researchers are trying to synthesize new molecules with anti-cancer properties. A class of organic compounds called thiosemicarbazones exhibit a broad spectrum of useful biological activities including anticancer and antimicrobial. One of the possible mechanisms of the anticancer action of thiosemicarbazones is the inhibition of topoisomerase IIα. In this article the synthetic procedure of some novel bis-thiosemicarbazones is described. Their topoisomerase IIα inhibition potential was estimated by Molecular Docking method.Item Obţinerea unor coloranţi din surse vegetale locale(CEP USM, 2024) Cojocaru, CiprianThis study aims to obtain and characterize natural dyes from local plant sources and agro-industrial waste for use in the food, cosmetic, and pharmaceutical industries. For this Soxhlet and combined extraction methods were used, followed by sample concentration and recrystallization. Microscopic and spectral (FT-IR) analyses confirmed the presence of the natural dyes. The study highlights the importance of using agro-industrial waste for sustainable products, reducing environmental impact, and contributing to the economic development of the Republic of Moldova.Item Sinteza unor 1-(N-feniltiocarbamoil)-2-pirazoline potenţial biologic active pe baza unor azacalcone(CEP USM, 2024) Vînagă, AndreeaItem Obţinerea unui gel cu proprietăţi potenţial cicatrizante şi antioxidante pe baza extractului de Aloe Vera(CEP USM, 2024) Panainte, ValeriaThe study involves investigating and applying methods for extracting Aloe Vera pulp, determining its chemical composition, and assessing its antioxidant activity. The extract is incorporated into a gel with potential antioxidant and wound-healing effects, and the quality of the finished product is evaluated. Research results indicate that Aloe pulp contains bioactive compounds and possesses antioxidant activity. A cream-gel has been formulated with Aloe extract, which meets all quality standards.Item Obţinerea unor forme stabilizate ale acidului ascorbic pentru utilizare în producerea cosmetică(CEP USM, 2024) Radu, ElenaThe study carried out focused on the use of the Fischer reaction to obtain three stabilized forms of ascorbic acid: ascorbyl palmitate, ascorbyl stearate and ascorbyl oleate. The objective of the work was to find the reaction parameters to obtain high yields in the production of esters, by testing different synthesis conditions.Item Sinteze de noi derivați benzochinolinici cu activitate anticanceroasă(CEP USM, 2024) Zbancioc, Gheorghită; Moldoveanu, Costel; Mangalagiu, IonelThis work synthesized various novel benzo[c]quinoline compounds, detailed their structural features, and examined their anticancer activity in vitro. First, the nitrogen atom in benzo[c]quinoline is quaternized, and the in situ-formed ylide is then subjected to a [3+2] dipolar cycloaddition reaction. A detailed investigation was conducted to determine how successful traditional thermal heating (TH) synthesis was in comparison to microwave (MW) and ultrasonic (US) irradiation. FTIR, HRMS, and NMR were the three spectral techniques that were used to prove the structure of all the obtained compounds. In an invitro single-dose anticancer experiment, all benzo[c]quinoline derivatives (quaternary salts and cycloadducts) that have previously been obtained were tested. The findings showed that the anticancer activity of the cycloadducts 5a-c and 6a-c is stronger than quaternary salts 3a-c. Compound 5a is the most active, exhibiting anticancer action on the majority of the cell lines examined, but compound 6c is the second most active, demonstrating notable mortality for the SR Leukemia cell line (17%). Correlations between the structure-activity relationship (SAR) are also included in the study.Item Synthesis and evaluation of new 2-azolylindoles – derivatives of indole-2-carboxylic acid(CEP USM, 2024) Țiuleanu, Pavel; Marenin, Ivan; Shchekotikhin, AndreiIndole-2-carboxylic acid is a promising scaffold for the design of new compounds with application in biological studies and medicine practice. Its derivatives have shown a wide range of biological activity: antiviral, antifungal, antibacterial, anti-inflammatory. As part of the presented study, the method for preparation of alkyl derivatives of acetoacetic ester has been optimized. These derivatives are intermediates for the synthesis of indole-2-carboxylic acid esters according to the Japp-Klingemann/Fisher methodology. Several methods for the transformation of indole-2-carboxylic acid ester into previously undescribed 2-azolilindoles - derivatives of triazole, thiadiazole and oxadiazole have been proposed. Acylthiosemicarbazide on indole-2-carboxylic acid scaffold has been used for synthesis of corresponded azoles. Depending on the reaction conditions, indole-2-carboxylic acid acylthiosemicarbazide is capable of undergoing intramolecular cyclization into one of the target azoles.Item Azine derivatives with antimicrobial properties(CEP USM, 2024) Mangalagiu, Violeta; Amăriucăi-Mantu, Dorina; Antoci, Vasilichia; Diaconu, Dumitrela; Mangalagiu, IonelAzine derivatives, especially pyridine, quinoline and their fused derivatives, are invaluable scaffolds in medicinal chemistry having a large variety of biological activities, antimicrobials including. In this work we present some recent results that we obtained in the field of azine with antibacterial, antifungal and antituberculosis activity. Some of the obtained results are very promising, the antimicrobial activity of some azine derivatives being spectacular.