SINTEZE DE NOI DERIVAȚI BENZOCHINOLINICI CU ACTIVITATE ANTICANCEROASĂ

Abstract

This work synthesized various novel benzo[c]quinoline compounds, detailed their structural features, and examined their anticancer activity in vitro. First, the nitrogen atom in benzo[c]quinoline is quaternized, and the in situ-formed ylide is then subjected to a [3+2] dipolar cycloaddition reaction. A detailed investigation was conducted to determine how successful traditional thermal heating (TH) synthesis was in comparison to microwave (MW) and ultrasonic (US) irradiation. FTIR, HRMS, and NMR were the three spectral techniques that were used to prove the structure of all the obtained compounds. In an invitro single-dose anticancer experiment, all benzo[c]quinoline derivatives (quaternary salts and cycloadducts) that have previously been obtained were tested. The findings showed that the anticancer activity of the cycloadducts 5a-c and 6a-c is stronger than quaternary salts 3a-c. Compound 5a is the most active, exhibiting anticancer action on the majority of the cell lines examined, but compound 6c is the second most active, demonstrating notable mortality for the SR Leukemia cell line (17%). Correlations between the structure-activity relationship (SAR) are also included in the study.