Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology
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Item SINTEZE DE NOI DERIVAȚI BENZOCHINOLINICI CU ACTIVITATE ANTICANCEROASĂ(CEP USM, 2024) Zbancioc, Gheorghită; Moldoveanu, Costel; Mangalagiu, IonelThis work synthesized various novel benzo[c]quinoline compounds, detailed their structural features, and examined their anticancer activity in vitro. First, the nitrogen atom in benzo[c]quinoline is quaternized, and the in situ-formed ylide is then subjected to a [3+2] dipolar cycloaddition reaction. A detailed investigation was conducted to determine how successful traditional thermal heating (TH) synthesis was in comparison to microwave (MW) and ultrasonic (US) irradiation. FTIR, HRMS, and NMR were the three spectral techniques that were used to prove the structure of all the obtained compounds. In an invitro single-dose anticancer experiment, all benzo[c]quinoline derivatives (quaternary salts and cycloadducts) that have previously been obtained were tested. The findings showed that the anticancer activity of the cycloadducts 5a-c and 6a-c is stronger than quaternary salts 3a-c. Compound 5a is the most active, exhibiting anticancer action on the majority of the cell lines examined, but compound 6c is the second most active, demonstrating notable mortality for the SR Leukemia cell line (17%). Correlations between the structure-activity relationship (SAR) are also included in the study.Item SYNTHESIS AND EVALUATION OF NEW 2-AZOLYLINDOLES – DERIVATIVES OF INDOLE-2-CARBOXYLIC ACID(CEP USM, 2024) Țiuleanu, Pavel; Marenin, Ivan; Shchekotikhin, AndreiIndole-2-carboxylic acid is a promising scaffold for the design of new compounds with application in biological studies and medicine practice. Its derivatives have shown a wide range of biological activity: antiviral, antifungal, antibacterial, anti-inflammatory. As part of the presented study, the method for preparation of alkyl derivatives of acetoacetic ester has been optimized. These derivatives are intermediates for the synthesis of indole-2-carboxylic acid esters according to the Japp-Klingemann/Fisher methodology. Several methods for the transformation of indole-2-carboxylic acid ester into previously undescribed 2-azolilindoles - derivatives of triazole, thiadiazole and oxadiazole have been proposed. Acylthiosemicarbazide on indole-2-carboxylic acid scaffold has been used for synthesis of corresponded azoles. Depending on the reaction conditions, indole-2-carboxylic acid acylthiosemicarbazide is capable of undergoing intramolecular cyclization into one of the target azoles.Item AZINE DERIVATIVES WITH ANTIMICROBIAL PROPERTIES(CEP USM, 2024) Mangalagiu, Violeta; Amăriucăi-Mantu, Dorina; Antoci, Vasilichia; Diaconu, Dumitrela; Mangalagiu, IonelAzine derivatives, especially pyridine, quinoline and their fused derivatives, are invaluable scaffolds in medicinal chemistry having a large variety of biological activities, antimicrobials including. In this work we present some recent results that we obtained in the field of azine with antibacterial, antifungal and antituberculosis activity. Some of the obtained results are very promising, the antimicrobial activity of some azine derivatives being spectacular.Item ROLUL COBALAMINEI ÎN PROCESELE DE AUTOPURIFICARE RADICALICĂ ÎN MEDIUL ACVATIC(CEP USM, 2024) Lis, Angela; Gladchi, Viorica; Blonschi, Vladislav; Cisteacov, Maxim; Bunduchi, ElenaThe main purpose of this research is to study the role of Cyanocobalamin (CNCbl) in aquatic ecosystems. The spectrophotometric method was used to determine the inhibition capacity and the concentration of OH radicals using PNDMA traps. As a result, it was found that, on the one hand, CNCbl is a reducing substance and leads to the consumption of oxidative equivalents, resulting in its oxidation. High inhibition capacity values and low OH radical values confirmed this. On the other hand, under irradiation, CNCbl can also act as a sensitizer. It actively absorbs photons in the UV and visible range, transitions to an excited state, and then transfers the electronic excitation energy to dissolved oxygen in water, forming active species such as singlet oxygen and superoxide radical anion. In the presence of protons, the superoxide radical anion is reduced to hydrogen peroxide, which generates OH radicals upon irradiation. From the obtained results, it can be seen that under the conditions of natural aquatic systems, CNCbl will not disturb the processes of radical self-purification.Item ACTIVITATEA ANTIOXIDANTĂ A FILMELOR CU EXTRACTE DIN PRODUSE VEGETALE DE SOPHORA JAPONICA L.(CEP USM, 2024) Grigoraș, Carolina; Ciocârlan, Alexandru; Gonţa, MariaPlant products of S. japonica, more precisely: flowers, fruits and seeds collected in May and September, respectively, have been conditioned, and the products obtained serve as a source of raw material. The extracts were obtained from the vegetable raw material by maceration, distillation and hydrodistillation using various solvents, with the subsequent incorporation into the filmogenic mixture of chitosan:pectin, to obtain polymeric films. The obtained films were evaluated according to quality indices, thus the appearance, smell and mechanical properties were analyzed, the thickness of the films was measured and antioxidant properties were determined. The prepared biomaterials are uniform, thin, elastic, flexible, have no smell and have a specific color of the composition, manifest an antioxidant activity, but this varies depending on the composition of the prepared films.Item SYNTHESIS AND BIOLOGICAL ACTIVITY OF N-(4-METHOXYPHENYL)-2-OXOPROPANAMIDE 4-PHENYLTHIOSEMICARBAZONE AND ITS COPPER(II) COMPLEXES(CEP USM, 2024) Graur, Ianina; Usataia, Irina; Graur, Vasilii; Tsapkov, Victor; Gulea, Aurelian; Garbuz, Olga; Balan, GretaThe new N-(4-methoxyphenyl)-2-oxopropanamide 4-phenylthiosemicarbazone (HL) and its 5 copper(II) coordination compounds [Cu(L)X] (X = Cl- (I); Br- (II); NO3- (III); CH3COO- (IV); Cl2CHCOO- (V)) have been synthesized and characterized by elemental analysis, FTIR and NMR spectra. Coordination of 4-phenylthiosemicarbazone HL with the copper(II) atom led to increased antibacterial activity against Staphylococcus aureus and Bacillus cereus. Non-coordinated 4-phenylthiosemicarbazone (HL) showed the highest activity in relation to ABTS•+ cation radicals; its activity is close to that of Trolox, which is used in medicine. The antibacterial and antioxidant activities of the synthesized complexes are influenced by the nature of the acidic residue in their composition.Item SPECTROSCOPIC PROPERTIES OF ZnPc(COOH)4/Ch/Fe3O4 SUPRAMOLECULAR ARCHITECTURES(CEP USM, 2024) Druță, Alexandrina; Lungu, Ion; Popușoi, Ana; Potlog, Tamara; Bulmaga, Petru; Rusnac, RomanThis paper presents the synthesis of ZnPc(COOH)4/Ch/Fe3O4 supramolecular architectures at various ZnPc(COOH)4 and Ch/Fe3O4 concentrations explored in the synthesis process. Ch/Fe3O4 composite was prepared by a simple solution mixing-evaporation method. The validation of the synthesis was achieved through FTIR analysis and UV-Vis spectroscopy. FTIR of composite indicated an interaction between chitosan and Fe3O4 NPs. The chemical interaction of ZnPc(COOH)4 with Ch/F3O4 composite is confirmed by the shift of the signal from ν(C=O)) of protonated COOH groups in the FTIR spectrum of ZnPc(COOH)4, associated with spitting, to (νsym(COO)) and (νasym(COO)) that correspond to deprotonated carboxylic group. The absorption spectra of ZnPc(COOH)₄ revealed IR Q band with two subbands situated at 640 nm 700 nm. Also, the effect of various ZnPc(COOH) and Ch/Fe3O4 concentrations on absorbance of ZnPc(COOH)4/Ch/Fe3O4 supramolecular architecture is discussed.Item STABILIREA IMPACTULUI POLUĂRII CU VITAMINA B6 ASUPRA CAPACITĂȚII DE AUTOPURIFICARE A SISTEMELOR ACVATICE NATURALE (LACURI)(CEP USM, 2024) Bunduchi, Elena; Gladchi, Viorica; Cisteacov, Maxim; Lis, Angela; Blonschi, Vladislav; Duca, GheorgheIn the framework of this research, it was aimed to establish which concentrations of vitamin B6 can be considered triggers of the pollution phenomenon in natural aquatic systems of the lentic type, such as the Danceni and Ghidighici lakes. The modeling was done on microcosm type systems. The pollution and auopurification processes were monitored according to the quality indicators for natural waters: pH, permanganateometric oxidizability (CCOMn), degree of saturation with dissolved oxygen (OD, mgO2/L) and inhibition capacity (Σki[Si], s-1). Research shows that natural waters can become vulnerable to vitamin B6 pollution in concentrations of the order of ≤ 0.5·10-4 M, because self-purification processes fail to eliminate the pollution caused by these concentrations, only slightly attenuating it. The consumption of active forms of oxygen, OH radicals, important particles of the chemical self-purification process of natural waters, highlight even more the negative impact of the pollution of aquatic systems with vitamin B6.Item COMPUȘI COORDINATIVI AI FIERULUI(III) CU UNELE TIOSEMICARBAZONE N(4) – SUBSTITUITE ALE DERIVAȚILOR SALICIL ALDEHIDEI ȘI CINAM ALDEHIDEI(CEP USM, 2024) Bîrcă, Maria; Rusnac, Roman; Gulea, AurelianIn this paper, the purpose of synthesis of Fe(III) coordination compounds with some N(4)-substituted thiosemicarbazones of salicyl aldehyde and cinnam aldehyde derivatives was pursued: which contain as a radical in the N(4) position: tert-butyl, cyclohexyl; allyl, methyl. The structure of thiosemicarbazones HnL1-5 was confirmed by FTIR spectroscopy and TLC analysis, melting point and NMR spectra. Based on the above-mentioned ligands, 5 coordination combinations were obtained, the research of which was carried out with the help of infrared spectroscopy. All synthesized compounds are being researched for their biological properties: antimicrobial and antifungal, as well as antioxidant capacities.Item SINTEZA DE NOI COMPLECŞI DE ZINC ȘI CUPRU DERIVAȚI DIN LIGANZI BISTRIAZOLICI(CEP USM, 2024) Al-Matarneh, Maria-Cristina; Şova, Sergiu; Nicolescu, Alina Florica; Danac, RamonaObiectivul studiului a constat în sinteza de liganzi continând un nucleu bifenilic grefat cu diverse unități 1,2,3-triazolice, precum și polimeri de coordinare ai acestora. Astfel, este prezentata sinteza și caracterizarea de noi liganzi pe baza de 1,1’-(3,3’-dimetoxi-[1,1’-bifenil]-4,4’-dil)-bis(4-butil-1H-1,2,3-triazol) (L1) și 1,1’-(3,3’-dimetoxi-[1,1’-bifenil]-4,4’-dil)-bis(4-fenil-1H-1,2,3-triazol) (L2), precum și polimerii acestora de coordinare cu Cu(II) și Zn(II). De asemenea, un polimer de coordinare neașteptat cu Cu(I) a fost obținut în cazul ligandului L2, pornind de la Cu(II). Liganzii și complecșii metalici au fost supuși unei caracterizări amănunțite, inclusiv difracție de raze X, spectroscopie NMR, FTIR, spectrometrie de masă (MS), EPR, XPS și analize TG-DTG. În timp ce ligandul L2 a generat un polimer liniar cu Cu(I), ligandul L1 a format un polimer în zigzag atât cu cupru, cât și cu zinc.