Repozitoriul Instituțional al Universității de Stat din Moldova (RI USM)

Institutional Repository of Moldova State University (IR MSU)

Repozitoriul Instituțional al Universității de Stat din Moldova reprezintă arhiva digitală cu acces deschis a rezultatelor cercetărilor științifice și științifico-didactice efectuate în cadrul universității. Conținutul arhivei este multidisciplinar și include lucrări din domeniile științelor exacte și socio-umanistice.
The Institutional Repository of the State University of Moldova is an open access digital archive of the results of scientific and scientific-didactic research carried out within the university. The archive's content is multidisciplinary and includes works from the fields of exact sciences, social sciences and humanities.

Communities in DSpace

Select a community to browse its collections.

Now showing 1 - 5 of 17

Recent Submissions

Investigații computaționale privind fezabilitatea reacției de esterificare dintre l-carnitină și acidul protocatecuic [Articol]
(2025) Arsene, Ion
This research explores the chiral behavior and conformational landscape of L-carnitine by vibrational circular dichrosis (VCD) spectroscopy correlated with density functional theory (DFT) calculations, as well as the thermodynamic and kinetic feasibility of its esterification reaction with protocatechical acid. The DFT simulations showed the existence of several energetically stable conformities, differentiated by distinct spectroscopic signatures in IR and VCD, significantly influenced by the solvent effect and the network of intramolecular hydrogen bonds. The comparison of the calculated spectra with the experimental IR data confirmed the attribution of characteristic vibrations (C=O, O–H), while the VCD bands allowed the differentiation of stable conformances, highlighting the potential of the method for conformational validation in solution. The analysis of the esterification mechanism showed that the reaction with protocatechuic acid is thermodynamically unfavorable and presents a high activation barrier, although the stabilization of intermediates by aromatic conjugation and hydrogen bonds partially contributes to the decrease in transition energy. The results obtained highlight the relevance of combining VCD spectroscopy with theoretical calculations for correlating the structure with the reactivity of L-carnitine, providing new insights on its biochemical role and interactions with food acids.
The development of the integrative and creative activity of the human brain through the involvement of human resources in neurotechnology and neuroengineering [Articol]
(Print-Caro, 2025) Baciu, Anatolie; Listopadova, Lyudmila
O sinteză bazată pe o revizuirea bibliografiei are ca scop o soluție conceptuală la problema îmbunătățirii activităților educaționale și a formării profesionale a resursei umane prin implicarea directă a acesteia în implementarea proiectelor din domeniul neurotehnologiilor. Se propune o integrare mai strânsă a realizărilor din științe ale naturii, medico-biologice și tehnologiile aferente în științele tehnice și inginerie, care, pe lângă importanța sa socio-economică semnificativă, oferă și o motivație puternică pentru activitatea intelectuală și inovatoare.
Necesitatea neuroprotecției centrale a mecanismelor neuroendocrine de asigurare a funcționalității sistemului reproducător [Articol]
(Print-Caro, 2025) Fedaş, Vasile; Mereuţă, Ion; Baciu, Anatolie
The paper is a review and synthesis of data that indicate the urgent need to develop programs to protect and improve the reproductive functionality of human resources, based primarily on the creation of environmental conditions conducive to daily activity. The presented data demonstrate the high sensitivity and vulnerability of fine neuroendocrine mechanisms regulating reproductive functionality at different stages of individual organism development. Also, the high socio-economic importance for the sustainable development of the morpho-functional state of the human reproductive system and the increased risk of unfavorable epig
Abordări filosofice ale sănătății creierului în era contemporană [Articol]
(Print-Caro, 2025) Mereuţă, Ion
Brain health cannolongerbe under stoodsolelythrough medical or biological paradigms. In the contemporary era, characterized by technological acceleration, existential stress, and profound social changes, a philosophical approach to human neurocognitive balance is necessary. This article explores the connections between philosophical concepts of consciousness, identity, and the meaningof lifeand brain health, proposing a transdisciplinary analysis. Philosophyc an contribute to the prevention and under standing of neuropsychicsuffering by fostering reflection, responsibility, and existential meaning.
The justificatory impediment in agricultural cooperatives’ contracts - legal solutions for economic resilience [Articol]
(2025) Praporşcic, Valeria
Contracts form the foundation of the economic activities of agricultural cooperatives, yet they are exposed to unpredictable external factors that may hinder the fulfillment of contractual obligations. The justificatory impediment, including force majeure, fortuitous events, and hardship, plays a crucial role in protecting contracting parties in such situations. However, existing regulations and legal mechanisms for managing these impediments are not always adapted to the specific needs of agricultural cooperatives, which depend on unstable climatic, economic, and geopolitical factors. The aim of this article is to analyze the impact of the justificatory impediment on the contracts of agricultural cooperatives and to propose legal solutions that enhance their economic resilience. The main objectives of the study are to identify the specific contractual vulnerabilities of agricultural cooperatives, examine the applicable legal mechanisms across different legal systems, and formulate recommendations for adapting legislation and contractual practices. The scientific novelty of this article lies in its interdisciplinary approach to the justificatory impediment, analyzing it from both contract law and economic sustainability perspectives. The relevance of this study stems from the need to develop effective legal mechanisms that ensure contractual balance and economic stability for cooperatives in the face of external risks, thereby contributing to the strengthening of the agricultural sector and the protection of farmers' interests