Molecule de o nouă generaţie cu proprietăţi anticancer [Articol]

Abstract

The present paper describes the synthesis and characterisation of novel copper, nickel and zinc complexes with the salicylidenthiosemicarbazones of general formula (X)NNHC( S)NH( Y) obtained from the condensation reaction of thiosemicarbazide (Y = H) or 4phenylthiosemicarbazide (Y = C6H5) with 2hydroxybenzaldehyde and its derivatives (X). The composition and structure of complexes were confirmed by elemental analysis, single crystal XRay Diffraction, IR, 1H NMR, 13C NMR spectroscopies, and magnetochemical, thermoanalytical and molar conductance measurements. All ligands and metal complexes were tested as inhibitors of cancer cells proliferation.