2. Articole

Permanent URI for this collectionhttps://msuir.usm.md/handle/123456789/46

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Author: search.filters.author.Rusnac, RomanSubject: search.filters.subject.anticancer activity

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    Synthesis of new bis-thiosemicarbazones based on 2,2’-[propane-1,3-diil-bis-(oxi)]dibenzaldehyde with biological potential [Articol]
    (CEP USM, 2024) Ciursin, Andrei; Rusnac, Roman; Gulea, Aurelian
    Cancer is the second most common cause of death. No known drug meets 100% the needs of the medical industry. For these reasons, many researchers are trying to synthesize new molecules with anti-cancer properties. A class of organic compounds called thiosemicarbazones exhibit a broad spectrum of useful biological activities including anticancer and antimicrobial. One of the possible mechanisms of the anticancer action of thiosemicarbazones is the inhibition of topoisomerase IIα. In this article the synthetic procedure of some novel bis-thiosemicarbazones is described. Their topoisomerase IIα inhibition potential was estimated by Molecular Docking method.
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    Sinteza unor Tiosemicarbazone în baza N-{4-(hidrazinilcarbonotioil)amino]fenil}acetamidei [Articol]
    (CEP USM, 2016) Rusnac, Roman; Rusnac, Anna; Garbuz, Olga; Babară, Nicanor; Gulea, Aurelian; ;
    În articol sunt descrise metodele de sinteză a şase compuşi organici, dintre care trei nu sunt cunoscuţi în literatura de specialitate. Structura compuşilor a fost eterminată cu ajutorul spectroscopiei: RMN 1H,13C şi IR. A fost studiată activitatea anticancer pe celule HeLa (cancer cervical), unde compusul N-[4-({2-[1-(piridin-2-il etltiliden]hidrazincarbotioil}amino) fenil]acet-amidă a prezentat cea mai mare pondere de inhibiţie (84%) la concentraţia de 100 μM/L.