In vitro anticancer activity of chloro(N-phenyl-N'-[(pyridin-2- yl)methylidene]carbamohydrazonothioato) (4-aminobenzene-1-sulfonamide)copper [Articol]
| dc.contributor.author | Garbuz, Olga | en |
| dc.date.accessioned | 2019-09-03T09:38:15Z | |
| dc.date.available | 2019-09-03T09:38:15Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | This study was aimed to evaluate the antiproliferative activity of the mixed-ligand complex (chloro(N-phenyl-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioato)(4-aminobenzene-1-sulfonamide)copper) on several cancer cells of lines. It was established, that the copper(II) mixed-ligand complex exhibits the highest anticancer activity against MeW-164, HeLa, BxPC-3 and RD cells of lines with IC50 values of 1.0±0.2, 0.4±0.04, 1.7±0.2, 1.3±0.3 μM, respectively. A comparative study between the tested compound and DOXO in regard to cancer lines has established that the tested copper(II) mixed-ligand complex exhibits stronger inhibitory activity on cancer cells proliferation than doxorubicin and cisplatin. | en |
| dc.description.abstract | Acest studiu a avut ca scop studierea activității antiproliferative a complexului (cloro(N-fenil-N'-[(piridin-2-il)metiliden]carbamohidrazontiolato)(4-aminobenzen-1-sulfonamid)-cupru) pe linii de celule cancerigene. S-a stabilit că complexul investigat cu cupru (II) prezintă cea mai mare activitate anticancerigenă împotriva celulelor liniilor MeW-164, HeLa, BxPC-3 și RD cu valori IC50 de 1,0±0,2, 0,4±0,04, 1,7±0,2, 1,3±0,3, respectiv. Studiul comparativ al compusului testat cu DOXO în ceea ce privește liniile de celule cancerigene a arătat că complexul testat de cupru (II) prezintă o activitate inhibitoare mai puternică asupra proliferării celulelor cancerigene decât doxorubicina și cisplatina. | ro |
| dc.identifier.citation | GARBUZ, Olga. In vitro anticancer activity of chloro(N-phenyl-N'-[(pyridin-2- yl)methylidene]carbamohydrazonothioato) (4-aminobenzene-1-sulfonamide)copper. Studia Universitatis Moldaviae. Seria Științe Reale și ale Naturii. 2018, nr. 6(116), pp. 70-76. ISSN 1814-3237. E-ISSN 1857-498X. | en |
| dc.identifier.issn | 1814-3237 | |
| dc.identifier.issn | 1857-498X | |
| dc.identifier.uri | https://ojs.studiamsu.md/index.php/stiinte_reale_naturii/article/view/1028/1226 | |
| dc.identifier.uri | https://msuir.usm.md/handle/123456789/2162 | |
| dc.language.iso | en | |
| dc.publisher | Universitatea de Stat din Moldova | ro |
| dc.subject | mixed-ligand complex | en |
| dc.subject | doxorubicin | en |
| dc.subject | cisplatin | en |
| dc.subject | anticancer activity | en |
| dc.subject | cancer cells of line | en |
| dc.subject | complex mixt-ligand | en |
| dc.subject | doxorubicină | ro |
| dc.subject | cisplatină | ro |
| dc.subject | activitate anticancerigenă | ro |
| dc.subject | linii de celule cancerigene | ro |
| dc.title | In vitro anticancer activity of chloro(N-phenyl-N'-[(pyridin-2- yl)methylidene]carbamohydrazonothioato) (4-aminobenzene-1-sulfonamide)copper [Articol] | en |
| dc.title.alternative | In vitro activitatea anticancerigenă a (cloro(n-fenil-N'-[(piridin-2-il)metiliden] carbamohidrazontiolato) (4-aminobenzen-1-sulfonamid)-cupru) | ro |
| dc.type | Article |