Micromolecular inhibitors of superoxide radicals [Articol]

dc.contributor.authorAndronache, Lilia
dc.contributor.authorPantea, Valeriana
dc.contributor.authorGulea, Aurelian
dc.contributor.authorȘveț, Inna
dc.contributor.authorGraur, Vasilii
dc.contributor.authorMatcovschi, Valerii
dc.contributor.authorGamaniuc, Marina
dc.contributor.authorGudumac, Valentin
dc.date.accessioned2023-10-20T13:08:33Z
dc.date.available2023-10-20T13:08:33Z
dc.date.issued2021
dc.description.abstractBackground: Currently, there is a growing interest in new copper (Cu2+) heterocyclic coordination compounds (CC), isothiosemicarbazide derivates, which demonstrated multiple beneficial properties, but their effect on reactions with free radicals such as the superoxide radical has not been investigated. Material and methods: The action of new micromolecular complexes of copper (Cu2+) chloride and bromide with methyl n- (prop-2-en-1-yl) -2- (pyridin2-ylmethylidene) hydrazine carbimidothioate on capturing activity of the superoxide radical was determined by the spectrophotometric method in vitro experiments. Results: It was established that the micromolecular complexes of copper (II) chloride and bromide with methyl n-(prop-2-en-1-yl)-2-(pyridin-2ylmethylidene) hydrazine carbimidothioate have been found to possess strong superoxide radical inhibitor properties when interacting with a superoxide radical. In addition to this, the IC50 of the studied compounds depends on the nature of the acid-ligand in the internal sphere of the complex and increases in the following sequence: Cl-–Br-. Conclusions: The established property of mentioned compounds is new, because their use as micromolecular inhibitors of superoxide radicals has not been described so far. The synthesized CC expand the arsenal of superoxide radical inhibitors with high biological activity. Their possible significance for the development of new treatment strategies for diseases associated with the overproduction of superoxide radicals is discussed.en
dc.description.sponsorshipThe authors express sincere thanks to the National Agency for Research and Development for the project offered (research grant No. 20.80009.5007.10).en
dc.identifier.citationANDRONACHE, Lilia, PANTEA, Valeriana, GULEA, Aurelian, ŞVEŢ, Inna, GRAUR, Vasilii , MATCOVSCHI, Valerii, GAMANIUC, Marina, GUDUMAC, Valentin. Micromolecular inhibitors of superoxide radicals. În: Moldovan Medical Journal, 2021, nr. 6(64), pp. 5-9. ISSN 2537-6373en
dc.identifier.issn2537-6373
dc.identifier.urihttps://msuir.usm.md/handle/123456789/11410
dc.identifier.urihttps://doi.org/10.52418/moldovan-med-j.64-6.21.01
dc.language.isoenen
dc.subjectsuperoxide radical inhibitorsen
dc.subjectcoordination compoundsen
dc.subjectisothiosemicarbazide derivatesen
dc.titleMicromolecular inhibitors of superoxide radicals [Articol]en
dc.typeArticleen

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