EVALUAREA BIOLOGICĂ A COMPUȘI LOR COORDINATIVI AI CUPRULUI(II) CU UNELE TIOSEMICARBAZONE HETEROCICLICE
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
CEP USM
Abstract
Au fost sintetizați 3 compuși noi: tiosemicarbazona 2-acetilpiridinei H2L, cloro(tiosemicarbazona-2-acetilpiridinei) cupru(II) (1) și nitrato(tiosemicarbazona-2-acetilpiridinei)cupru(II) (2) care potențial posedă proprietăți antiproliferative fată de celulele canceroase. Doxorubicina (7-[4-amino-5-hidroxi-6-metiloxan-2-il]oxi-6,9,11-trihidroxi-9-(2-hidroxiacetil)4-metoxi-8,10-dihidro-7H-tetracen-5,12-dionă) a fost utilizată în calitate de compus anticancerigen de referință și Trolox (acid 6-hidroxi-2,5,7,8-tetramethilcroman-2-carboxilic) a fost utilizat ca compus antioxidant de referință. Compușii testați au demonstrat efect antioxidant înalt față de cationii radicali ABTS•+ în comparație cu interacțiunea acestor cationi cu Trolox. Compușii testați au manifestat toxicitate generală față de Daphnia magna după 24 de ore de expunere cu determinarea unui șir de descreștere. Datele experimentale au indicat perspectivele pentru viitoare căutări ale substanțelor anticancerigene selective cu acțiune antioxidantă înaltă și toxicitate scăzută.
Three new compounds were synthesized: thiosemicarbazone 2-acetylpyridine H2L, chlor (thiosemicarbazone 2acetylpyridine) dicopper(II) (1) and (thiosemicarbazone 2-acetylpyridine) dicopper(II) nitrate (2) which potentially possesses antiproliferative properties toward cancer cells. Doxorubicin (7-[4-amino-5-hydroxi-6-methyloxan-2-il]oxi6,9,11-trihydroxi-9-(2-hydroxiacetyl)-4-metoxi-8,10-dihydro-7H-tetracen-5,12-dion) was used as the reference anticancer compound and Trolox (acid 6-hydroxi-2,5,7,8-tetramethilcroman-2-carboxilic) was used as the reference antioxidant compound. The tested compounds demonstrated a high antioxidant effect against ABTS•+ radical cations than interaction with Trolox. The tested compounds showed general toxicity on Daphnia magna after 24 hours of exposure with a determination of decreasing string. The experimental data indicated the prospects for further search for selective anticancer substances with high antioxidant activity and low toxicity among tested compounds.
Three new compounds were synthesized: thiosemicarbazone 2-acetylpyridine H2L, chlor (thiosemicarbazone 2acetylpyridine) dicopper(II) (1) and (thiosemicarbazone 2-acetylpyridine) dicopper(II) nitrate (2) which potentially possesses antiproliferative properties toward cancer cells. Doxorubicin (7-[4-amino-5-hydroxi-6-methyloxan-2-il]oxi6,9,11-trihydroxi-9-(2-hydroxiacetyl)-4-metoxi-8,10-dihydro-7H-tetracen-5,12-dion) was used as the reference anticancer compound and Trolox (acid 6-hydroxi-2,5,7,8-tetramethilcroman-2-carboxilic) was used as the reference antioxidant compound. The tested compounds demonstrated a high antioxidant effect against ABTS•+ radical cations than interaction with Trolox. The tested compounds showed general toxicity on Daphnia magna after 24 hours of exposure with a determination of decreasing string. The experimental data indicated the prospects for further search for selective anticancer substances with high antioxidant activity and low toxicity among tested compounds.
Description
Keywords
activitate antioxidantă, ABTS radical cation, Trolox, tiosemicarbazonă, toxicitate, Daphnia magna, Doxorubicină
Citation
GARBUZ, Olga; RAILEAN, Nadejda; GOSTEV, Igor; RUSNAC, Anna; TODERAŞ, Ion; GULEA, Aurelian. Evaluarea biologică a compuși lor coordinativi ai cuprului(II) cu unele tiosemicarbazone heterociclice. In: Studia Universitatis Moldaviae. Seria Ştiinţe Reale şi ale Naturii. 2022, nr. 6(156), pp. 144-149. ISSN 1814-3237.10.5281/zenodo.7445721