THE ANTIPROLIFERATIVE, ANTIOXIDANT ACTIVITIES AND TOXICITY OF MIXED-LIGAND AMINE-CONTAIN- ING COPPER(II) COORDINATION COMPOUNDS WITH 2-(2-HYDROXYBENZYLIDENE)-N-(PROP-2-EN-1-YL)HY- DRAZINECARBOTHIOAMIDE
| dc.contributor.author | Garbuz, Olga | |
| dc.contributor.author | Toderas, Ion | |
| dc.contributor.author | Ulchina, Ianina | |
| dc.contributor.author | Graur, Vasile | |
| dc.contributor.author | Railean, Nadejda | |
| dc.contributor.author | Gulea, Аurelian | |
| dc.date.accessioned | 2023-10-03T12:41:20Z | |
| dc.date.available | 2023-10-03T12:41:20Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Five compounds 2-(2-Hydroxybenzylidene)-N-(prop-2-en1-yl)hydrazinecarbothioamide (H2L), bis[μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl) phenolato-S,N,O:O] diaquadicopper (II) nitrate (1), bis [μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl)phenolato-S,N,O:O]d iimidazoldicopper(II) nitrate (2), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper(II) nitrate hexahydrate (3), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl) phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds towards cancer cell lines HeLa, RD and normal cell line MDCK have been investigated. The tested compounds demonstrated high antioxidant and antiproliferative, selective activities towards cancer cells. Direct toxic evaluation of compounds was performed by Daphnia magna bioassay. | en |
| dc.description.sponsorship | 20.80009.7007.12 Diversitatea artropodelor hematofage, a zoo şi fitohelminţilor, vulnerabilitatea, strategiile de tolerare a factorilor climatici şi elaborarea procedeelor inovative de control integrat al speciilor de interes socio-economic 20.80009.7007.23 Identificarea, evaluarea şi perfecţionarea unor noi procedee de sporire a ratei de creştere a peştilor, de diminuare a impactului maladiilor şi de îmbunătățire a valorificării furajelor în cadrul instalaţiilor piscicole de tip închis alimentate cu apă circulantă | en |
| dc.identifier.citation | GARBUZ, Olga, TODERASH, Ion, ULCHINA, Ianina, GRAUR, Vasilii О., RAILYAN, Nadejda, GULYA, A.. The Antiproliferative, Antioxidant Activities and Toxicity of Mixed-Ligand Amine-Containing Copper (II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(Prop-2-En-1-Yl) Hydrazinecarbothioamide. In: Sustainable use and protection of animal world in the context of climate change: dedicated to the 75th anniversary from the creation of the first research subdivisions and 60th from the foundation of the Institute of Zoology, Ed. 10, 16-17 septembrie 2021, Chișinău. Chișinău: Institutul de Zoologie, 2021, Ediția 10, pp. 123-129. ISBN 978-9975-157-82-7. DOI: 10.53937/icz10.2021.20 | en |
| dc.identifier.isbn | 978-9975-157-82-7 | |
| dc.identifier.uri | ||
| dc.identifier.uri | https://doi.org/10.53937/icz10.2021.20 | |
| dc.identifier.uri | https://msuir.usm.md/handle/123456789/11106 | |
| dc.language.iso | en | en |
| dc.title | THE ANTIPROLIFERATIVE, ANTIOXIDANT ACTIVITIES AND TOXICITY OF MIXED-LIGAND AMINE-CONTAIN- ING COPPER(II) COORDINATION COMPOUNDS WITH 2-(2-HYDROXYBENZYLIDENE)-N-(PROP-2-EN-1-YL)HY- DRAZINECARBOTHIOAMIDE | en |
| dc.type | Article | en |