The Antiproliferative, Antioxidant Activities and Toxicity of Mixed-Ligand Amine-Containing Copper (II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(Prop-2-En-1-Yl) Hydrazinecarbothioamide [Articol]
| dc.contributor.author | Garbuz, Olga | |
| dc.contributor.author | Toderaș, Ion | |
| dc.contributor.author | Ulchina, Ianina | |
| dc.contributor.author | Graur, Vasile | |
| dc.contributor.author | Railean, Nadejda | |
| dc.contributor.author | Gulea, Aurelian | |
| dc.date.accessioned | 2023-10-20T12:45:59Z | |
| dc.date.available | 2023-10-20T12:45:59Z | |
| dc.date.issued | 2021-09-16 | |
| dc.description.abstract | Five compounds 2-(2-Hydroxybenzylidene)-N-(prop-2-en1-yl)hydrazinecarbothioamide (H2L), bis[μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl) phenolatoS,N,O:O] diaquadicopper (II) nitrate (1), bis [μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl)phenolato-S,N,O:O]d iimidazoldicopper(II) nitrate (2), bis[μ2-2-({2-[(prop-2en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper( II) nitrate hexahydrate (3), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl) phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds towards cancer cell lines HeLa, RD and normal cell line MDCK have been investigated. The tested compounds demonstrated high antioxidant and antiproliferative, selective activities towards cancer cells. Direct toxic evaluation of compounds was performed by Daphnia magna bioassay. | en |
| dc.description.sponsorship | The study was carried out within Project 20.80009.7007.12: “Diversity of he- matophage arthropods, zoo- and phytohelmints, vulnerability, strategies to tolerate climate factors and elaboration of innovative integrated control processes of species of socio-economic interest” within the Institute of Zoology and the project 20.80009.7007.23: “Identification, evaluation and improvement of new procedures to increase the growth rate of fish, reduce the impact of diseases and improve the use of feed in closed fish farms fed by circular water” within the Moldova State University. | en |
| dc.identifier.citation | GARBUZ, Olga, TODERAȘ, Ion, ULCHINA, Ianina, GRAUR, Vasile , RAILEAN, Nadejda, GULEA, Aurelian. The Antiproliferative, Antioxidant Activities and Toxicity of Mixed-Ligand Amine-Containing Copper (II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(Prop-2-En-1-Yl) Hydrazinecarbothioamide. În: Sustainable use and protection of animal world in the context of climate change: dedicated to the 75th anniversary from the creation of the first research subdivisions and 60th from the foundation of the Institute of Zoology, Ed. 10, 16-17 septembrie 2021, Chișinău, 2021, pp. 123-129. ISBN 978-9975-157-82-7 | en |
| dc.identifier.isbn | 978-9975-157-82-7 | |
| dc.identifier.uri | https://msuir.usm.md/handle/123456789/11409 | |
| dc.identifier.uri | https://doi.org/10.53937/icz10.2021.20 | |
| dc.language.iso | en | en |
| dc.title | The Antiproliferative, Antioxidant Activities and Toxicity of Mixed-Ligand Amine-Containing Copper (II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(Prop-2-En-1-Yl) Hydrazinecarbothioamide [Articol] | en |
| dc.type | Article | en |