Novel 2‐formylpyridine 4‐allyl‐S‐methylisothiosemicarbazone and Zn(II), Cu(II), Ni(II) and Co(III) complexes: Synthesis, characterization, crystal structure, antioxidant, antimicrobial and antiproliferative activity [Articol]

Abstract

New zinc (II), copper (II), nickel (II) and cobalt (III) complexes, [Zn (HL) 2 ]I 2(1), [Cu (HL)Cl2 ](2), [Cu (HL)Br2](3), [Cu (HL)(H2O)2](ClO4)2(4), [Ni (HL)2]I2H2O(5), [Co(L)2]Cl (6), [Co(L)2]NO3(7), [Co(L)2]I[Co(L)2](I3) (8) were obtained with 2-formylpyridine 4-allyl-Smethylisothiosemicarbazone (HL). The isothiosemicarbazone ligand was characterized by NMR (1H and13C), IR spectroscopy and X-ray diffraction. All the complexes were characterized by elemental analysis, IR, UV–Vis, ESI-MS spectroscopy, molar conductivity, magnetic susceptibility measurements. X-ray diffraction analysis on the monocrystal and powder elucidated the structure of the complexes 1,5, 7and 8. The ligand and the complexes were tested for their antioxidant and antimi-crobial activity against Staphylococcus aureus,Escherichia coli,Klebsiella pneumoniae and Candida albicans. Also, the antiproliferative properties of these compounds on human leukemia HL-60, human cervical epithelial HeLa, human epithelial pancreatic adenocarcinoma BxPC-3, human muscle rhabdomyosarcoma spindle, large multinucleated RD cells and normal MDCK cells have been investigated. The nickel complex 5and cobalt complexes 6,7showed promising antiproliferative activity and low toxicity