COORDINATION COMPOUNDS OF COPPER WITH 2-FORMYLPYRIDINE 4-(DIMETHYLPHENYL)THIOSEMICARBAZONES

Abstract

2-Formylpyridine 4-(2,6-dimethylphenyl)-(HL1), 4-(2,5-dimethylphenyl)-(HL2), 4-(3,4-dimethylphenyl)-(HL 3), and 4-(2,4-dimethylphenyl)thiosemicarbazones (HL4) react with copper chloride and nitrate to form coordination compounds CuL 1-4X·nH2O [X = Cl-, NO3 -; n = 1, 2]. All compounds have a polynuclear structure. Azomethines HL1-4 act as the bridging monodeprotonated tridentate N,N,S-ligands. The thermolysis of the complexes includes the dehydration (70-90 C) and total thermal decomposition (350-520 C). The complexes synthesized exhibit a selective antimicrobial activity against a series of standard strains of Staphylococcus aureus and Escherichia coli in the concentration range of 0.009-37.5 μg ml-1