Novel 2-formylpyridine 4-allyl-S-methylisothiosemicarbazone and Zn(II), Cu(II), Ni(II) and Co(III) complexes: Synthesis, characterization, crystal structure, antioxidant, antimicrobial and antiproliferative activity [Articol]

dc.contributor.authorBalan, Greta
dc.contributor.authorUsataia, Irina
dc.contributor.authorGraur, Vasilii
dc.contributor.authorCiumacov, Iurie
dc.contributor.authorPetrenko, Peter
dc.contributor.authorGudumac, Valentin
dc.contributor.authorGulea, Aurelian
dc.contributor.authorPahonțu, Elena
dc.contributor.authorBurduniuc, Olga
dc.date.accessioned2023-10-26T08:48:44Z
dc.date.available2023-10-26T08:48:44Z
dc.date.issued2019
dc.description.abstractNew zinc (II), copper (II), nickel (II) and cobalt (III) complexes, [Zn (HL)2]I2 (1), [Cu (HL)Cl2] (2), [Cu (HL)Br2] (3), [Cu (HL)(H2O)2](ClO4)2 (4), [Ni (HL)2]I2·H2O (5), [Co(L)2]Cl (6), [Co(L)2]NO3 (7), [Co(L)2]I·[Co(L)2](I3) (8) were obtained with 2-formylpyridine 4-allyl-S-methylisothiosemicarbazone (HL). The isothiosemicarbazone ligand was characterized by NMR (1H and 13C), IR spectroscopy and X-ray diffraction. All the complexes were characterized by elemental analysis, IR, UV–Vis, ESI-MS spectroscopy, molar conductivity, magnetic susceptibility measurements. X-ray diffraction analysis on the monocrystal and powder elucidated the structure of the complexes 1, 5, 7 and 8. The ligand and the complexes were tested for their antioxidant and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Candida albicans. Also, the antiproliferative properties of these compounds on human leukemia HL-60, human cervical epithelial HeLa, human epithelial pancreatic adenocarcinoma BxPC-3, human muscle rhabdomyosarcoma spindle, large multinucleated RD cells and normal MDCK cells have been investigated. The nickel complex 5 and cobalt complexes 6, 7 showed promising antiproliferative activity and low toxicity.en
dc.identifier.citationBALAN, Greta, BURDUNIUC, Olga, USATAIA, Irina, GRAUR, Vasilii , CIUMACOV, Iurie, PETRENKO, Peter , GUDUMAC, Valentin, GULEA, Aurelian, PAHONȚU, Elena. Novel 2-formylpyridine 4-allyl-S-methylisothiosemicarbazone and Zn(II), Cu(II), Ni(II) and Co(III) complexes: Synthesis, characterization, crystal structure, antioxidant, antimicrobial and antiproliferative activity. În: Applied Organometallic Chemistry, 2020, vol. 34, pp.1-17. ISSN 0268-2605en
dc.identifier.issn0268-2605
dc.identifier.urihttps://msuir.usm.md/handle/123456789/11471
dc.identifier.urihttps://doi.org/10.1002/aoc.5423
dc.language.isoenen
dc.subjectantimicrobial activityen
dc.subjectantioxidant activityen
dc.subjectantiproliferative activityen
dc.subjectcomplexesen
dc.subjectcrystal structureen
dc.titleNovel 2-formylpyridine 4-allyl-S-methylisothiosemicarbazone and Zn(II), Cu(II), Ni(II) and Co(III) complexes: Synthesis, characterization, crystal structure, antioxidant, antimicrobial and antiproliferative activity [Articol]en
dc.typeArticleen

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