Studiul procesului de nitrozare a antibioticelor (cloramfenicolul) și elaborarea metodelor de inhibiţie [Articol]

Abstract

In the present work, was studied the nitrosating process of Chloramphenicol, an antibiotic, with a broad spectrum of activity, according to pH, substrate concentration and the concentration of nitrite ions. In accordance with the results obtained it was found that a higher consumption of ion nitrite is carried out at a more acidic pH, so the mechanism of nitrosating include participation cation NO+, which is formed mainly in the pH ≤ 2. Also, the speed of the nitrosation depend on the concentration of nitrosating substrate and of nitrite found in system, so increasing the concentration of the amine or nitrite, increases nitrosating reaction speed.