SYNTHESIS AND BIOLOGICAL ACTIVITY OF COPPER(II) COORDINATION COMPO UNDS WITH 2 - HYDROXY - 1 - NAPHTHALDEHYDE N (4) - ALLYL - 3 - THIOSEMICARBAZONE

Abstract

The paper presents the synthesis of the 2-hydroxy-1-naphthaldehyde N(4)-allyl-3-thiosemicarbazone (H2L) and seven coordinationcompounds of copper with this ligand and heteroaromatic amines. The new obtained compounds were investigated by elemental analysis, IR spectroscopy and molar electric conductibility. For the ynthesized compounds the antibacterial and antifungal activities in vitro were studied on a series of standard strains, such as Staphylococcus aureus (ATCC 25923),Bacillus cereus (ATCC 11778),Bacillus subtilis (ATCC 6633), Candida albicans (ATCC 10231) andCandida krusei (ATCC 6258). The nature of heteroaromatic amines influences the activity of the oordination compounds that decreases in the following way: 3,4-Lut > 1,10-Phen > 2,2’-Bpy > Py > 4-Pic > 3 -Pic. Almost all stuied substancesmanifest high antioxidant activity towards ABT S•+that exceeds the activity of Trolox which is used as standard antioxidant.

Lucrarea conţine descrierea sintezei N(4)-alil -3-tiosemicarbazonei 2-hidroxi-1-naftaldehidei (H2L) şi a şapte compuşi coordinativiai cuprului cu acest ligand și amine heteroaromatice. Compușii nou-obținuți au fost studiați cu ajutorul spectroscopiei IR,analizei elementale şi al conductivitaţii molare. Pentru compușii sintetizați a fost studiată in vitroactivitatea antibacteriană şi antifungică selectivă faţa de spectrul larg de tulpini standard de Staphylococcus aureus (ATCC 25923), Bacillus cereus (ATCC 11778), Bacillus subtilis (ATCC 6633), Candida albicans (ATCC 10231)şi Candida krusei (ATCC6258).Natura aminelor hete roaromatice influențează activitatea compușilor coordinativi și scade în felul următor:3,4-Lut > 1,10-Phen > 2,2’-Bpy > Py > 4-Pic > 3 -Pic. Metoda ABTS•+a demonstrat că aproximativ toţi compușii studiaţi manifestă o activitate antioxidantă mai pronunțată comparativ cu Trolox.