Institutul de Fiziologie si Sanocreatologie

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Author: search.filters.author.Poleacova, Lilia

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    Rolul aminoacizilor liberi în funcționalitatea sanogenă a sistemului imunitar
    (Editura USM, 2024) Garaeva, Svetlana; Postolati, Galina; Poleacova, Lilia
    The immune system, in connection with its functional tasks, is key in protecting the body from pathogenic external and internal factors. The formation of sanogenic homeostasis of the immune system depends on the intake of immunoactive amino acids into the body and the content in the blood, among which dicarboxylic amino acids are of greatest importance. An analysis of the literature allows us to conclude that the maintenance of sanogenic immunity is regulated by the level of intake of proteinogenic, primarily essential, amino acids into the body. The most significant for maintaining sanogenic homeostasis of the immune system are aromatic, branched-chain and sulfur-containing amino acids.
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    INFAMAȚIA SISTEMICĂ CRONICĂ ȘI MECANISMELE DE DECLANȘARE A PROCESELOR PARAMETABOLICE
    (CEP USM, 2024) Mereuță, Ion; Baciu, Anatolie; Poleacova, Lilia; Fedaș, Vasile
    The paper discusses the mechanisms of the primary occurrence of obesity through the ac tivation of the pro-inflammatory system, which ultimately lead to the occurrence of meta-inflam mation. The study of immunometabolism includes two main aspects: 1) the effects of the immune system on organs and tissues through the control of systemic metabolism; 2) the influence of the metabolic state of the bioenergetic organism through immune cells. Obesity as a heterogeneous multifactorial chronic disease is characterized by a wide pre valence, progressive increase in morbidity, high cardiometabolic risk. Central and peripheral obesity with insulin resistance (IR) is closely associated with type II DM. Several mechanisms are involved in the genesis of impaired insulin sensitivity: lipotoxicity, glucotoxicity, endoplasmic reticulum stress (degradation of damaged proteins in the cell), mitochondrial dysfunction, oxi dative stress and chronic inflammation in metabolically active tissues (adipose tissue, intestines, muscles, pancreas, liver).