Institutul de Fiziologie si Sanocreatologie

Permanent URI for this communityhttps://msuir.usm.md/handle/123456789/13384

Browse

Author: search.filters.author.Mereuță, Ion

Search Results

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
  • Thumbnail Image
    Item
    Morfofuncționalitatea mitocondrială în evoluția spermatogenezei la mamifere
    (Editura USM, 2024) Balan, Ion; Surai, Peter; Marin, Paula Monica; Balacci, Sergiu; Roșca, Nicolae; Buzan, Vladimir; Petcu, Igor; Mereuță, Ion; Osipciuc, Galina; Popa, Valerian; Vîhrist, Ecaterina
    In spermatogenesis, mitochondria are particularly important for the development and maintenance of germ cells and the production of healthy gametes. Deficiencies in these processes lead to mitochondrial dysfunction and abnormal spermatogenesis. The classical roles of mitochondria in energy production, metabolism and apoptosis have been well defined, but they also have various other functions. Mitochondria are also involved in testosterone production, regulating proton secretion in the lumen to maintain an acidic state in the epididymis, and condensing sperm DNA. In the available literature on sperm mitochondria, it is increasingly recognized that the morphology and functional status of mitochondria has a significant impact on sperm characteristics. Although mitochondria are recognized as essential for sperm, their exact pathophysiological role and functioning are complex. Understanding and managing mitochondrial quality control could be a valuable approach for developing new strategies in the physiological evolution of spermatogenesis.
  • Thumbnail Image
    Item
    INFAMAȚIA SISTEMICĂ CRONICĂ ȘI MECANISMELE DE DECLANȘARE A PROCESELOR PARAMETABOLICE
    (CEP USM, 2024) Mereuță, Ion; Baciu, Anatolie; Poleacova, Lilia; Fedaș, Vasile
    The paper discusses the mechanisms of the primary occurrence of obesity through the ac tivation of the pro-inflammatory system, which ultimately lead to the occurrence of meta-inflam mation. The study of immunometabolism includes two main aspects: 1) the effects of the immune system on organs and tissues through the control of systemic metabolism; 2) the influence of the metabolic state of the bioenergetic organism through immune cells. Obesity as a heterogeneous multifactorial chronic disease is characterized by a wide pre valence, progressive increase in morbidity, high cardiometabolic risk. Central and peripheral obesity with insulin resistance (IR) is closely associated with type II DM. Several mechanisms are involved in the genesis of impaired insulin sensitivity: lipotoxicity, glucotoxicity, endoplasmic reticulum stress (degradation of damaged proteins in the cell), mitochondrial dysfunction, oxi dative stress and chronic inflammation in metabolically active tissues (adipose tissue, intestines, muscles, pancreas, liver).