Institutul de Fiziologie si Sanocreatologie

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Author: search.filters.author.Leorda, AnaEnd date: 2024

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    FACTORI INTRINSECI CU IMPACT SANOGEN ASUPRA PROCESULUI DE DIGESTIE ÎN INTESTINUL SUBȚIRE
    (CEP USM, 2024) Şeptiţchi, Vladimir; Leorda, Ana
    The purpose of this article is to identify, based on an analysis of specialized literature and previously obtained own data, intrinsic factors of a sanogenic nature that affect the digestion process in the small intestine. Modern approaches have been formulated about the digestion of nutrients in the small intestine, its main stages, the cellular elements directly involved in its implementation and the regulatory mechanisms that ensure the sanogenic level of digestive processes. Based on an analysis of the literature and previously obtained experimental data, a series of intrinsic factors with a sanogenic character were identified, at the level of cellular elements and organs that directly ensure digestion in the small intestine and the nervous and hormonal regulation of digestion in the small intestine.
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    IMPACTUL SANO- ȘI DISSANOGEN AL DIETEI ASUPRA HOMEOSTAZIEI MICROBIOTEI INTESTINALE ȘI RELAȚIA ACESTEIA CU METABOLISMUL AMINOACIZILOR
    (CEP USM, 2024) Leorda, Ana; Garaeva, Svetlana; Tolstenco, Dorina
    Despite extensive scientific evidence supporting the relationship between dietary factors and gut microbiota composition and function, the underlying mechanisms and their potential impact are far from clear. Thus, the paper aim is to elucidate the components of the diet with a sanogenic and dissanogenic impact on the intestinal microbiota and its relationship with amino acid metabolism. Food intake has an indisputable impact on the development of the intestinal microbiota. The individual intestinal microbiota, while remaining relatively stable in a healthy organism, can vary qualitatively and quantitatively under of internal and external factors influence. The diet protein component targeted modification can regulate the functioning of microbial populations, which determines the sanogenicity of the body’s homeostasis.
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    ROLUL AMINOACIZILOR ÎN REGLAREA HOMEOSTAZIEI TRACTULUI GASTROINTESTINAL
    (CEP USM, 2024) Garaeva, Svetlana; Leorda, Ana; Postolati, Galina
    Influența aminoacizilor liberi asupra tractului gastrointestinal are loc, pe de o parte, prin aminoacizii care circulă în sânge, iar pe de altă parte, prin activitatea hepatică și a metabolomului intestinal. Menținerea nivelului sanogen al homeostaziei acestui sistem este strâns legată de aprovizionarea cu aminoacizi esențiali prin intermediul alimentelor. Aportul în organism a cantității optime de aminoacizi proteinogeni reglează menținerea nivelului sanogen al homeostaziei organelor și țesuturilor tractului gastrointestinal. Cei mai semnificativi sunt aminoacizii aromatici și cei cu lanț ramificat, care reglează activitatea ficatului, pancreasului și sinteza acizilor grași. Menținerea unui nivel normal de mucus intestinal este asociată cu aportul alimentar de treonină, serină, prolină și cisteină. Aminoacizii sulfurați pot fi considerați unul dintre mijloacele nespecifice de reglare și menținere a nivelului sanogen al homeostaziei tractului gastrointestinal.
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    Factorii alimentari sano- și dissanogeni, comuni pentru microbiocenoza intestinală și sistemul reproducător masculin
    (Editura USM, 2024) Leorda, Ana; Furdui, Vlada; Tolstenco, Dorina
    Diet composition is the most important extrinsic factor influencing individual differences in intestinal microbiota, and nutritional factors play a key role in determining reproductive health and can positively or negatively influence human fertility. Thus, extrinsic factors with a sanogenic character are of particular importance, which on the one hand have a positive impact on MI, and this in turn on the reproductive system, and on the other hand directly influence this system. The healthy and unhealthy aspects of the food ration with a common impact on the intestinal microbiocenosis and the reproductive system have been identified, since understanding the factors that contribute to affecting MI and decreasing male fertility is crucial for minimizing their impact. The role of intermittent fasting in maintaining the health of these two systems was also elucidated, as well as the effects of alcohol depending on the dose used.
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    Particularitățile hidrolizei membranare și a absorbției glucidelor în intestinul subțire la șobolanii albi în funcție de stresoreactivitatea constituțională
    (Editura USM, 2024) Grosul-Raileanu, Olesea; Șeptițchi, Vladimir; Leorda, Ana
    The aim of this work is to clarify the features of membrane hydrolysis of maltose and the absorption of glucose formed during hydrolysis, as well as free glucose and fructose in the small intestine of rats with different levels of constitutional stress reactivity. Significant differences in the intensity of free glucose and fructose absorption, membrane hydrolysis of maltose and absorption of glucose formed during hydrolysis were found in rats with different levels of constitutional stress reactivity. The highest rate of free glucose absorption is observed in animals with an average level of stress reactivity, and fructose - in animals with a low level of reactivity; the lowest rate of free monosaccharide absorption is observed in animals with high stress reactivity. Animals with an average level of constitutional reactivity have a higher intensity of membrane hydrolysis of maltose and glucose formed during hydrolysis compared to animals with high stress reactivity. The obtained data indicate the existence of a connection between the genetically determined stress reactivity of the body and the digestive-transport function of the small intestine.
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    The relationship of the intestinal microflora and reproductive health (Review)
    (Editura USM, 2024) Furdui, Vlada; Ciobanu, Elena; Leorda, Ana; Balan, Ion
    În prezent, există o creștere pe scară largă a interesului pentru microflora intestinală și impactul acesteia asupra sănătății și bolilor umane. Acest articol prezintă sinteză narativă privind interrelația dintre microbiomul intestinal și sănătatea reproductivă. Sunt studiate atât patologiile sistemului de reproducere feminin asociate cu disbioza intestinală, cât și relația dintre microbiota intestinală și funcția de reproducere a bărbaților. Cercetările viitoare ar trebui să se orienteze pe identificarea mecanismelor moleculare care stau la baza relației cauzale dintre microbiota intestinală și sănătatea reproducerii.
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    MODIFICĂRILE CANTITATIVE ȘI CALITATIVE ALE MICROBIOTEI INTESTINALE CA PREDICTOR PRECOCE AL CANCERULUI COLORECTAL
    (CEP USM, 2024) Leorda, Ana; Șeptițchi, Vladimir; Tolstenco, Dorina
    As a pressing global health problem, colorectal cancer (CRC) requires effective therapeutic strategies, and the underlying mechanisms remain an essential subject of investigation in this field. The problem of identifying some predictive markers of the probability of the appearance of this type of malignant neoplasms is quite current. Disturbance of the normal community of intes tinal bacteria represents an important problem in the development of CRC, thus new predictive markers of the probability of the appearance of this type of malignant neoplasms can be identi fied in changes in the qualitative and quantitative composition of the intestinal microbiota (MI). The subsequent development of preparations based on previously identified indigenous medicinal plants, which on the one hand have an anti-cancer effect, and on the other hand possess prebiotic properties, stimulate the multiplication of normal intestinal microbial flora. Targeted formation and maintenance of normal intestinal microbiota will be the basis for the development of new strategies in the prevention and treatment of CRC.