Institutul de Fiziologie si Sanocreatologie

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Author: search.filters.author.Fedaș, Vasile

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    INFAMAȚIA SISTEMICĂ CRONICĂ ȘI MECANISMELE DE DECLANȘARE A PROCESELOR PARAMETABOLICE
    (CEP USM, 2024) Mereuță, Ion; Baciu, Anatolie; Poleacova, Lilia; Fedaș, Vasile
    The paper discusses the mechanisms of the primary occurrence of obesity through the ac tivation of the pro-inflammatory system, which ultimately lead to the occurrence of meta-inflam mation. The study of immunometabolism includes two main aspects: 1) the effects of the immune system on organs and tissues through the control of systemic metabolism; 2) the influence of the metabolic state of the bioenergetic organism through immune cells. Obesity as a heterogeneous multifactorial chronic disease is characterized by a wide pre valence, progressive increase in morbidity, high cardiometabolic risk. Central and peripheral obesity with insulin resistance (IR) is closely associated with type II DM. Several mechanisms are involved in the genesis of impaired insulin sensitivity: lipotoxicity, glucotoxicity, endoplasmic reticulum stress (degradation of damaged proteins in the cell), mitochondrial dysfunction, oxi dative stress and chronic inflammation in metabolically active tissues (adipose tissue, intestines, muscles, pancreas, liver).
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    ROLUL MICROBIOTEI INTESTINALE ÎN MENȚINEREA STĂRII IMUNOMETABOLICE ȘI PREVENIREA METAINFLAMAȚIEI
    (CEP USM, 2024) Fedaș, Vasile
    The results of scientific research indicate that an important role in the pathogenesis of obe sity and the metabolic syndrome is played by the intestinal microbiota (MI), which is involved in the regulation of the host’s metabolism through symbiotic interactions with it. At the same time, a shift in the gut’s microbial ecosystem, according to cutting-edge research, contributes to signi ficant metabolic and immune disturbances in animals and humans. The environment and diet in the first 3 years of life are essential for the acquisition of an adult type of microbiota and the for mation of a microbiota-host symbiosis, which significantly affects the development of the immune and nervous systems. Although the microbiota is very diverse in the intestines, for example, there are representatives of about 70 types of bacteria, however, most of them are represented by two types: Bacteroidetes and Firmicutes.