Institutul de Fiziologie si Sanocreatologie

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Author: search.filters.author.Balan, IonEnd date: 2024

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    INFLUENȚA FACTORILOR INTRINSECI ȘI EXTRINSECI ASUPRA DEZVOLTĂRII CELULELOR SOMATICE ȘI GERMINALE
    (CEP USM, 2024) Balan, Ion; Gavojdian, Dinu; Roşca, Nicolae; Balacci, Serghei; Buzan, Vladimir; Furdui, Vlada; Osipciuc, Galina; Harea, Vasile
    Mammalian spermatogenesis is the most complex regulated process of cell development and represents a specific physiological process for the study of the peculiarities of the mechanism of spermatogenesis and for perceiving the basic evolution of all developmental processes, since it involves specific molecular processes of somatic and sex cells. Spermatogenesis generates spermatozoa from spermatogonal stem cells through several stages and comprises spermatocytogenesis, meiosis and spermiogenesis with the continuous unfolding of molecular events of mitosis, meiosis and epigenetic dynamic changes at the morphological and molecular level. Spermatogenesis establishes some dynamic changes by overlapping the functions of different types of cells and is maintained by different physiological factors impacting testicular morphofunction. The existing overlaps complicate the conclusive elucidation of the individual roles of different somatic and germ cells in the self-renewal, proliferation and apoptosis of spermatogonial stem cells and create difficulties in understanding the contribution of distinct signaling molecules during spermatogenesis. Several factors, compounds secreted by all somatic cells, including Sertoli cells, peritubular myoid cells and Leydig cells are involved in the regulation and development of spermatogenesis, but the mechanisms by which these factors interact in somatic and germ cells are largely unknown and a comprehensive study of these cells is needed.
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    Morfofuncționalitatea mitocondrială în evoluția spermatogenezei la mamifere
    (Editura USM, 2024) Balan, Ion; Surai, Peter; Marin, Paula Monica; Balacci, Sergiu; Roșca, Nicolae; Buzan, Vladimir; Petcu, Igor; Mereuță, Ion; Osipciuc, Galina; Popa, Valerian; Vîhrist, Ecaterina
    In spermatogenesis, mitochondria are particularly important for the development and maintenance of germ cells and the production of healthy gametes. Deficiencies in these processes lead to mitochondrial dysfunction and abnormal spermatogenesis. The classical roles of mitochondria in energy production, metabolism and apoptosis have been well defined, but they also have various other functions. Mitochondria are also involved in testosterone production, regulating proton secretion in the lumen to maintain an acidic state in the epididymis, and condensing sperm DNA. In the available literature on sperm mitochondria, it is increasingly recognized that the morphology and functional status of mitochondria has a significant impact on sperm characteristics. Although mitochondria are recognized as essential for sperm, their exact pathophysiological role and functioning are complex. Understanding and managing mitochondrial quality control could be a valuable approach for developing new strategies in the physiological evolution of spermatogenesis.
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    Proprietățile celulelor stem spermatogoniale în mediul nișelor fiziologice și metabolice testiculare
    (Editura USM, 2024) Balan, Ion; Gavojdian, Dinu; Budevici, Alexandr; Roșca, Nicolae; Buzan, Vladimir; Balacci, Sergiu; Osipciuc, Galina; Furdui, Vlada; Harea, Vasile; Cretu, Roman; Bacu, Gheorghe; Țurcanu, Parascovia; Temciuc, Vlad; Filippov, Artiom
    Spermatogenesis is a continuous process, maintained by the self-renewal and differentiation of spermatogonial stem cells (SSC), which arise from undifferentiated precursors (gonocytes) in the physiological conditions of the testicular cell niche. SSC serve as the foundation for the physiology of continuous spermatogenesis, they have the ability to self-renew by differentiation to produce spermatozoa suitable for fertilization, therefore the knowledge of the regulatory processes of SSC is of great importance for understanding the fundamental molecular mechanisms of the function of these cells in spermatogenesis. By strict physiological regulation, spermatogonial transitions occur with a complete non-exploitation of equivalent changes in metabolism, a conserved overregulation of mitochondrial function, biogenesis and oxidative phosphorylation in spermatogony differentiation, as well as the relationship between metabolism and the external microenvironment. In the present paper we have tried to review the current state of research in CSS physiology and biology, as well as their molecular regulation, in the physiological and metabolic niches, necessary for fundamental investigations and possible practical applications. Elucidation of the exact mechanisms and characteristics of testicular maturation events and gonocyte transition to SSC by activation of CSS-specific pathways or early embryonic establishment of transcriptional profiling of neonatal and prepubertal spermatogonia will contribute to new achievements of biological, physiological and metabolic aspects of SSC. Increased knowledge regarding the biology, physiology and metabolism of SSC will improve our understanding of the possibilities of applying SSC tools and manipulations in the evolution of spermatogenesis mechanisms.
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    Sănătatea societății contemporane – problemă globală ce amenință viitorul civilizației. Rezolvarea problemei sănătății e posibilă doar prin dezvoltarea sanocreatologiei
    (Editura USM, 2024) Furdui, Teodor; Ciochină, Valentina; Furdui, Vlada; Vudu, Stela; Priseajniuc, Victoria; Glijin, Aliona; Balan, Ion; Vrabie, Valeria; Jitari, Iurii
    The paper examines the problem of somato-vegetative health of the contemporary population as one of the most important, which determines the future of civilization. The analysis of the bibliographic literature indicates the insufficient study of the systems and mechanisms that determine the formation,maintenance and deterioration of health, as a specific phenomenon that ensures the human vitality and daily activity. Based on the literature and special own studies, the definition of somatovegetative health, physiological and psychical indicators of health identification, determinants of the formation and deterioration of health were developed and argued. Evidence is provided in support of the statement of the way to solve the health problem - the development of sanocreatology, science about creating,maintaining, strengthening health of the human organism and preventing its premature deterioration.
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    The relationship of the intestinal microflora and reproductive health (Review)
    (Editura USM, 2024) Furdui, Vlada; Ciobanu, Elena; Leorda, Ana; Balan, Ion
    În prezent, există o creștere pe scară largă a interesului pentru microflora intestinală și impactul acesteia asupra sănătății și bolilor umane. Acest articol prezintă sinteză narativă privind interrelația dintre microbiomul intestinal și sănătatea reproductivă. Sunt studiate atât patologiile sistemului de reproducere feminin asociate cu disbioza intestinală, cât și relația dintre microbiota intestinală și funcția de reproducere a bărbaților. Cercetările viitoare ar trebui să se orienteze pe identificarea mecanismelor moleculare care stau la baza relației cauzale dintre microbiota intestinală și sănătatea reproducerii.
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    INFLUIENȚA EXTRACTULUI DE POLIFENOLI DIN NUCILE VERZI ASUPRA METABOLISMULUI GLUTATIONULUI DIN SERIUL SANGUIN AL COCOȘILOR
    (CEP USM, 2024) Roșca, Nicolae; Balan, Ion; Buzan, Vladimir; Balacci, Sergiu; Furdui, Vlada; Mereută, Ion; Osipciuc, Galina; Crețu, Roman; Bacu, Gheorghii
    In this paper, the influence of polyphenol extract from green walnuts on glutathione metabo lism in the blood serum of breeding roosters was studied. To achieve this purpose, hydroalcoholic extract from green walnuts was used, with a total antioxidant activity of 548,37 mg gallic acid equivalent/100 gr. For the study were used two batches of roosters, of five animals in each batch, experimental and control. As a result of the research on the influence of metabolism, changes were obtained in the content of SH-groups, G-TP, G-S-T, as well as amino acids, which are part of the glutathione composition and which were studied in different biological fluids and repro ductive cells. The basic mechanism of the central role of thiol-mediated redox control in cellular metabolism is the ability of thiol groups to reversibly change their redox state with subsequent changes in the conformational, catalytic or regulatory functions of the protein.