Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology

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End date: 2018Subject: search.filters.subject.coordination compounds

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    Coordination compounds of cobalt, nickel, copper, and zinc with N 1,N 2-bis (pyridin-2-ylmethylidene)benzene-1,2-diamine and its derivatives [Articol]
    (2014) Pahonțu, Elena; Gulea, Aurelian; Poirier, Donald; Țapcov, Victor
    o-Phenylenediamine reacts with 2-formyl-, 2-acetyl-, or 2-benzoylpyridine in ethanol in the presence of cobalt, nickel, copper, or zinc chlorides to form monomeric complexes ML1-3Cl2·nH2O {M = Co, Ni, Cu, Zn; L1 = N 1,N 2-bis(pyridin-2-ymethylidene)benzene-1,2-diamine, L2 = N 1,N 2-bis(pyridin-2-ylethylidene) benzene-1,2-diamine, L3 = N 1,N 2-bis[phenyl(pyridin-2-yl)methylidene]benzene-1,2-diamine; n = 0-3}. The condensation products (L1-L3) act in the complexes as tetradentate N,N,N,N-ligands. Thermolysis of the complexes occurs in two stages: dehydration (70-95°C) and complete degradation (320-450°C). At concentrations of 10-5-10-7 M, the complexes inhibit in vitro growth and proliferation of HL-60 human promyelocytic leukemia cells.
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    Coordination chemistry in the Republic of Moldova [Articol]
    (2009) Bulhac, Ion; Gulea, Aurelian; Batâr, Dumitru
    This article is dedicated to the history of apparition and development of Coordination chemistry in Moldova. The main scientific centres are characterized, as well as their main research directions. The most valuable results in fundamental and applicative research are described, obtained in the field of coordination chemistry in the republic.
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    Synthesis and antimicrobial activity of coordination compounds of copper with substituted salicylaldehyde thiosemicarbazones [Articol]
    (Springer, 2005) Prisakar, V. I.; Tsapkov, V. I.; Buracheeva, S.A.; Byrke, M.S.; Gulya, A. P.
    New coordination compounds of copper(II) with thiosemicarbazones of 5-chloro-, 5-bromo-, 5-nitro-, 5-methyl-, 3,5-dichloro-, and 3,5-dibromo-substituted salicylaldehyde have been synthesized and tested with respect to eight strains of staphyloccoccus, streptococcus, and colon bacillus. These compounds exhibit high antimicrobial activity. The composition and structure of the synthesized complexes have been studied by means of elemental analysis and by magnetochemical, IR, and thermogravimetric techniques. The antimicrobial activity of the obtained coordination compounds depends both on the nature of substituents in the benzene ring of salicylaldehyde and on the nature of acid ligands. The maximum antimicrobial activity was observed for copper(II) complexes with thiosemicarbazone of 3,5-dibromsalicyladehyde.
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    Synthesis, characterization and biological activity of copper(ii), nickel(II), cobalt(III) and iron(III) coordination compounds with 2-hydroxy-3-methoxybenzaldehyde n(4)-allyl-s-methylisothiosemicarbazone [Articol]
    (CEP USM, 2018) Usataia, Irina; Graur, Vasilii; Tsapcov, Victor; Gulea, Aurelian
    The paper presents the synthesis of the 2-hydroxy-3-methoxybenzaldehyde N(4)-allyl-S-methylisothiosemicarbazone (HL) and seven coordination compounds of copper, nickel, cobalt and iron with this ligand. The new obtained compounds were studied using IR, 1H and 13C NMR spectroscopy, elemental analysis, molar electric conductibility and magnetic susceptibility. The in vitro antiproliferative activity of the HL and synthesized coordination compounds was screened on HeLa cancer cells and normal MDCK cells. The isothiosemicarbazone HL shows better anticancer activity towards HeLa cancer cells than doxorubicin that is used in medical practice and it also practically does not affect the growth and proliferation of normal cells. Moreover, it manifests high antioxidant activity towards ABTS•+ radical cation that exceeds the activity of trolox.
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    Synthesis , characterization and biological activity of copper(II), nickel(II), cobalt(III) and iron(III) coordination compounds with 1-(2-hydroxyphenyl)ethanonen(4)-allyl-s-methylisothiosemicarbazone [Articol]
    (CEP USM, 2018) Usataia, Irina
    The paper presents the synthesis of the 1-(2-hydroxyphenyl)ethanone N(4)-allyl-S-methylisothiosemicarbazone (HL) and seven coordination compounds of copper, nickel, cobalt and iron with this pro-ligand. The newly obtained compounds were investigated by IR, 1H and 13C NMR spectroscopy, elemental analysis, molar electric conductibility and magnetic susceptibility. For the synthesized compounds the antibacterial and antifungal activities in vitro were studied on a series of standard strains, such as Staphylococcus aureus (ATCC 25923), Escherihia coli (ATCC 25922), Klebsiella pneumonae and Candida albicans. The in vitro antiproliferative activity of the pro-ligand and complexes was screened on Hep-2, BxPC-3, RD cancer cellsand normal MDCK cells. It was established that coordination compounds manifest better antiproliferative activity than the proligand.
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    Synthesis and biological activity of copper(II), nickel(II) and cobalt(III) coordination compounds with 2-benzoylpyridine N(4)-allyl-S-methylisothiosemicarbazone [Articol]
    (2018) Usataia, Irina; Graur, Vasilii; Zariciuc, Elena; Garbuz, Olga; Gulea, Aurelian
    The paper presents the synthesis of the 2-benzoylpyridine N(4)-allyl-S-methylisothiosemicarbazone and five coordination compounds of copper(II), nickel(II) and cobalt(III) with this ligand. New synthesized substances were studied using IR and NMR (1H and 13C) spectroscopies, elemental analysis, molar conductivity and magnetochemical research. It was studied in vitro antimicrobial and antifungal activities against a wide range of standard strains Staphylococcus aureus (ATCC 25923), Escherihia coli (ATCC 25922), Klebsiella pneumonae and Candida albicans for synthesized substances. The study of the antiproliferative properties in vitro of the pro-ligand and complexes was tested on the human myeloid leukemia HL-60 and cervical cancer HeLa cells..
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    Sinteza şi structura compuşilor coordinativi ai cuprului(II) cu tiosemicarbazona aldehidei 5-(metilentrimetilamoniu)salicilice [Articol]
    (CEP USM, 2016) Sîrbu, Angela; Secu, Mihail; Bouroș, Polina; Palamarciuc, Oleg
    A fost sintetizată clorura tiosemicarbazonei aldehidei 5-(metilentrimetilamoniu)salicilice în formă de sare ((H2L)Cl•1.5H2O), iar la interacţiunea acesteia cu diferite săruri de cupru(II) în mediu neutru au fost obţinuţi patru compuşi cu formulele [Cu(HL)Cl]Cl•2.25H2O (1), Cu(HL)(Cl)(NO3)]•2H2O (2), [Cu(H2L)Cl]SO4•0.75H2O (3) şi [Cu(HL)Cl]ClO4•1.75H2O (4), ce au fost stabilite cu ajutorul razelor X. Trei compuşi ai cuprului sunt compuşi ionici, formaţi din cationul complex [Cu(HL)Cl]+ori [Cu(H2L)Cl]2+, anionii fiind Cl-, ClO4- şi SO42- respectiv, iar compusul ce conţine anionul NO3-este un complex molecular. Toţi compuşii conţin molecule de apă de solvatare. Liganzii (HL)0/(H2L)+în 1, 2, 4/3coordinează tridentat prin setul de atomi donori O,N,S în formă de ion bipolar, singur fiind electroneutru, însă conţinând două centre ionice (Zwitter-ion) ori în forma sa protonată, respectiv. Raportul molar de combinare Cu:(HL)0/(H2L)+în aceşti compuşi este 1:1. În rezultatul coordinării liganzii organici (HL)0/(H2L)+suferă schimbări conformaţionale, iar primii sunt supu şi monodeprotonării.
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    Sinteza, structura şi proprietăţile compuşilor coordinativi ai fierului cu 4-Feniltiosemicarbazona şi 4-Fenil-s-metiltiosemicarbazona 2-Acetilpiridinei [Articol]
    (CEP USM, 2016) Palamarciuc, Tatiana; Sîrbu, Angela; Palamarciuc, Oleg
    În acest articol este realizată sinteza compuşilor Fe(III) cu 4-feniltiosemicarbazona şi 4-fenil-S-metiltiosemicarbazona 2-acetilpiridinei, fiind propus studiul cristalografic şi magnetic al acestor compuşi cât şi studiul spectrofotometric în soluţie pentru ionii Fe(II) cu aceiaşi liganzi. Compuşii coordinativi [Fe(L1)2]BF4•CH3OH (1) şi [Fe(L2)2]FeCl4(2) au fost obţinuţi în soluţii alcoolice. Analiza cu raze X relevăfaptul cămetilarea atomului de sulf influenţează asupra modului de coordinare a liganzilor la ionul de Fe(III). Compuşii 1şi 2 manifestă proprietăţi magnetice diferite.
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    Biotestarea şi estimarea toxicităţii compuşilor metalooragnici asupra populaţiei de Paramecium caudatum [Articol]
    (CEP USM, 2016) Toderaș, Ion; Gulea, Aurelian; Roșcov, Elena; Garbuz, Olga
    În articol este studiată influenţa unor grupuri de substane metaloorganice asupra microorganismelor acvatice. Este utilizată metoda de biotestare toxicologică a compuşilor coordinativi CMT-28 şi CMA-18 asupra ciliatelor Paramecium caudatum Ehrnbg,în concentraţii de 100, 10, 1, 0,1, 0,01 uM/L, comparativ cu prototipul. Metoda de biotestare ne permite să formulăm rapid concluzii în plan comparat, evitând riscul unei erori înalte.Proprietăţile compuşilor metaloorganici au fost cercetate prin metoda diluărilor în serie, în mediul nutritiv lichid (1 g soluţie nutritivă/1 l apă). În calitate de culturi de referinţăau fost folosite ciliatele Paramecium caudatm. Infuzoriile, ca obiecte de cercetare, sunt foarte comode, se reproduc destul de rapid, fiind cele mai convenabile test-obiecte pentru investigaţii în condiţii de laborator, în care factorul timp joacăun rol decesiv, inclusiv pentru elucidarea impactului unor factori abiotici (substanţelor metaloorganice) asupra procesului de reproducere asexuatăla Paramecium caudatum. Activitatea substanţelor a fost evaluată după caracterul toxicităţii preparatelor (LT50 şi LC50), iar activitatea ciliatelor a fost studiată după caracterul viabilităţii şi parametrii reproductivi (creşterea sau diminuarea efectivului numeric şi a ratei lor de reproducere). Toxicitatea acută(LT50 şi LC50) a compuşilor a fost cercetată conform recomandărilor metodice privind studierea toxicităţii generale a remediilor farmaceutice. LC50(concentraţia letală, 50%) – concentraţia care cauzează moartea a 50% din test-organisme într-o anumită perioadă de timp. LT50(timpul letal, 50%) – timpul în care concentraţia utilizată a compusului testat cauzează moartea a 50% din organismele testate.
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    Design and synthesis of coordination compounds with tetradentate ligands derived from alkylated thiosemicarbazide [Articol]
    (Institute of Chemistry of ASM, 2008) Cocu, M.; Gradinaru, J.; Revenco, M.; Rybak-Akimova, E.; Gărbălău, N.
    This work is devoted to the investigation of the template reactions of organic compounds derived from S-alkylisothiosemicarbazide and β-dicarbonylic compounds (acetyl(benzoyl)acetone, 2,6-diformylpyridine, 2,6-diformyl-4-methylphenol, 1-hydroxy-2-naphthaldehyde, sodium nitromalonic dialdehyde, 1,1,3,3-tetraetoxypropane, 3-ethoxyacroleine) in the presence of 3d-metal ions, determination of the structure and properties of the prepared complexes. There were elaborated original methods for synthesis of open-chain or macrocyclic coordination compounds of nickel(II), copper(II), oxovanadium(IV) and cobalt(II) with N4, N3O and N2O2 tetradentate ligands. Two types of hexaazamacrocyclic systems with trans- and cis- arrangement of thiosemicarbazide.