Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology

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Author: search.filters.author.Ciursin, Andrei

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    Synthesis of new bis-thiosemicarbazones based on 2,2’-[propane-1,3-diil-bis-(oxi)]dibenzaldehyde with biological potential [Articol]
    (CEP USM, 2024) Ciursin, Andrei; Rusnac, Roman; Gulea, Aurelian
    Cancer is the second most common cause of death. No known drug meets 100% the needs of the medical industry. For these reasons, many researchers are trying to synthesize new molecules with anti-cancer properties. A class of organic compounds called thiosemicarbazones exhibit a broad spectrum of useful biological activities including anticancer and antimicrobial. One of the possible mechanisms of the anticancer action of thiosemicarbazones is the inhibition of topoisomerase IIα. In this article the synthetic procedure of some novel bis-thiosemicarbazones is described. Their topoisomerase IIα inhibition potential was estimated by Molecular Docking method.
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    Synthesis, computational pharmacokinetics report, admet study and molecular docking of new thiosemicarbazones potential inhibitors of her2 - positive breast cancer [Articol]
    (CEP USM, 2024) Rusnac, Roman; Ciursin, Andrei; Gulea, Aurelian
    To maintain a high level of healthcare, humanity needs to develop new drugs. Thiosemicarbazones represent a very interesting class of substances from the point of view of their biological activities. Despite this, their use is very limited due to their toxicity. To solve this problem, it is possible to synthesize thiosemicarbazones based on natural substances. This can reduce their toxicity without loss of effectiveness. a number of computational methods can be used for the design and preliminary evaluation of thiosemicarbazones, which will help eliminate many unsuitable candidates. This will help reduce the cost and speed up the pace of development of new effective substances from this class. such methods include aDMeT calculations and molecular docking.
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    Synthesis and biotechnological study of ethyl 2-((E)-2-((E) phenylallylidene) hydrazinecarbothioamido) acetate [Articol]
    (CEP USM, 2024) Ciursin, Andrei; Trofim, Alina; Rusnac, Roman
    The quality and length of human life is directly related to the development of medicine, in particular drugs. The modern world is constantly in the process of developing new, more effective drugs. Thiosemicarbazones may be one of the promising solutions. Despite their outstanding biological activities, many of them are toxic and cannot be used as medicines. The solution may be thiosemicarbazones, which are based on natural substances. This is expected to signifcantly reduce toxicity without impairing the biological activity of the substances. In this regard, for this work, a thiosemicarbazone was synthesized, which is based on two natural substances, glycine and cinnamaldehyde. To test the toxicity of this substance, some strains of cyanobacteria were used in this article. In addition to the lack of toxicity to these microorganisms, the synthesized thiosemicarbazone had a biostimulating effect.
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    Sinteza şi studiul unor tiosemicarbazone ale cinamaldehidei şi derivaţilor ei cu potenţial biologic [Articol]
    (Editura USM, 2024) Ciursin, Andrei
    The ever-increasing incidence of cancer and diabetes and the development of antibiotic resistance necessitate the development of new drugs. Promising candidates for this role are thiosemicarbazones. Some representatives of this class of organic substances are already used in medicine. However, their high toxicity limits their use. Also, the effectiveness of these substances strongly depends on the structure of the substituents used. In this work, thiosemicarbazones based on the natural substance cinnamaldehyde and its derivatives were synthesized. These substances were investigated using NMR, FTIR and X-ray diffraction. Pharmacokinetic properties were studied based on calculations of the parameters of the Lipinski rule and molecular-docking. Biological studies have been carried out on cyanobacteria as well as antioxidative activity.
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    Sinteza și analiza fizico-chimică a compușilor coordinativi ai Cu(II) în baza 4-ciclohexil-tiosemicarbazonei 3-etoxisalicilice [Articol]
    (CEP USM, 2023) Rusnac, Roman; Ciursin, Andrei; Șova, Sergiu; Sîrbu, Angela; Gulea, Aurelian
    În acest articol sunt descrise metode de sinteză și analiza fizico-chimică a 5 compuși coordinativi în baza ionului de Cu(II) și 4-ciclohexil-tiosemicarbazona aldehidei 3-etoxisalicilice. În primul pas a fost efectuată sinteza ligandului prin intermediul a două metode clasice cu perfecționarea ulterioară, obținându-se astfel H2L în calitate de chelator al ionilor de cupru(II). Pentru cercetarea structuri și geometria 4-ciclohexil- tiosemicarbazonei aldehidei 3-etoxisalicilice a fost aplicată spectroscopia 1H, 13C și 15N-RMN, 13C- DEPT-135 RMN și 15N HSQC-RMN. Substanțele sintetizate au fost analizate prin intermediul metodelor moderne de cercetare precum: spectroscopia FTIR, UV- vis și analizei elementale, difracția razelor X pe monocristal; activitatea biologică este în proces de studiu.
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    Synthesis of n-cyclohexyl-2-[(3-ethoxy-2- hydroxyphenyl) methylidene] hydrazine-1- carbothioamide [Articol]
    (CEP USM, 2022-09-29) Ciursin, Andrei; Rusnac, Roman; Gulea, Aurelian
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    Sinteza și analiza n-ciclohexil-2-[di(piridin-2-il)metiliden] hidrazin-1-carbotioamidei [Articol]
    (CEP USM, 2022-11-10) Rusnac, Roman; Ciursin, Andrei; Gulea, Aurelian