2. Articole

Permanent URI for this collectionhttps://msuir.usm.md/handle/123456789/13386

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Subject: search.filters.subject.intestinal microbiota

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    IMPACTUL SANO- ȘI DISSANOGEN AL DIETEI ASUPRA HOMEOSTAZIEI MICROBIOTEI INTESTINALE ȘI RELAȚIA ACESTEIA CU METABOLISMUL AMINOACIZILOR
    (CEP USM, 2024) Leorda, Ana; Garaeva, Svetlana; Tolstenco, Dorina
    Despite extensive scientific evidence supporting the relationship between dietary factors and gut microbiota composition and function, the underlying mechanisms and their potential impact are far from clear. Thus, the paper aim is to elucidate the components of the diet with a sanogenic and dissanogenic impact on the intestinal microbiota and its relationship with amino acid metabolism. Food intake has an indisputable impact on the development of the intestinal microbiota. The individual intestinal microbiota, while remaining relatively stable in a healthy organism, can vary qualitatively and quantitatively under of internal and external factors influence. The diet protein component targeted modification can regulate the functioning of microbial populations, which determines the sanogenicity of the body’s homeostasis.
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    Factorii alimentari sano- și dissanogeni, comuni pentru microbiocenoza intestinală și sistemul reproducător masculin
    (Editura USM, 2024) Leorda, Ana; Furdui, Vlada; Tolstenco, Dorina
    Diet composition is the most important extrinsic factor influencing individual differences in intestinal microbiota, and nutritional factors play a key role in determining reproductive health and can positively or negatively influence human fertility. Thus, extrinsic factors with a sanogenic character are of particular importance, which on the one hand have a positive impact on MI, and this in turn on the reproductive system, and on the other hand directly influence this system. The healthy and unhealthy aspects of the food ration with a common impact on the intestinal microbiocenosis and the reproductive system have been identified, since understanding the factors that contribute to affecting MI and decreasing male fertility is crucial for minimizing their impact. The role of intermittent fasting in maintaining the health of these two systems was also elucidated, as well as the effects of alcohol depending on the dose used.
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    MODIFICĂRILE CANTITATIVE ȘI CALITATIVE ALE MICROBIOTEI INTESTINALE CA PREDICTOR PRECOCE AL CANCERULUI COLORECTAL
    (CEP USM, 2024) Leorda, Ana; Șeptițchi, Vladimir; Tolstenco, Dorina
    As a pressing global health problem, colorectal cancer (CRC) requires effective therapeutic strategies, and the underlying mechanisms remain an essential subject of investigation in this field. The problem of identifying some predictive markers of the probability of the appearance of this type of malignant neoplasms is quite current. Disturbance of the normal community of intes tinal bacteria represents an important problem in the development of CRC, thus new predictive markers of the probability of the appearance of this type of malignant neoplasms can be identi fied in changes in the qualitative and quantitative composition of the intestinal microbiota (MI). The subsequent development of preparations based on previously identified indigenous medicinal plants, which on the one hand have an anti-cancer effect, and on the other hand possess prebiotic properties, stimulate the multiplication of normal intestinal microbial flora. Targeted formation and maintenance of normal intestinal microbiota will be the basis for the development of new strategies in the prevention and treatment of CRC.