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Morfofuncționalitatea mitocondrială în evoluția spermatogenezei la mamifere
(Editura USM, 2024) Balan, Ion; Surai, Peter; Marin, Paula Monica; Balacci, Sergiu; Roșca, Nicolae; Buzan, Vladimir; Petcu, Igor; Mereuță, Ion; Osipciuc, Galina; Popa, Valerian; Vîhrist, Ecaterina
In spermatogenesis, mitochondria are particularly important for the development and maintenance of germ cells and the production of healthy gametes. Deficiencies in these processes lead to mitochondrial dysfunction and abnormal spermatogenesis. The classical roles of mitochondria in energy production, metabolism and apoptosis have been well defined, but they also have various other functions. Mitochondria are also involved in testosterone production, regulating proton secretion in the lumen to maintain an acidic state in the epididymis, and condensing sperm DNA. In the available literature on sperm mitochondria, it is increasingly recognized that the morphology and functional status of mitochondria has a significant impact on sperm characteristics. Although mitochondria are recognized as essential for sperm, their exact pathophysiological role and functioning are complex. Understanding and managing mitochondrial quality control could be a valuable approach for developing new strategies in the physiological evolution of spermatogenesis.