2. Articole

Permanent URI for this collectionhttps://msuir.usm.md/handle/123456789/13386

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Author: search.filters.author.Furdui, VladaHas files: Yes

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    INFLUENȚA FACTORILOR INTRINSECI ȘI EXTRINSECI ASUPRA DEZVOLTĂRII CELULELOR SOMATICE ȘI GERMINALE
    (CEP USM, 2024) Balan, Ion; Gavojdian, Dinu; Roşca, Nicolae; Balacci, Serghei; Buzan, Vladimir; Furdui, Vlada; Osipciuc, Galina; Harea, Vasile
    Mammalian spermatogenesis is the most complex regulated process of cell development and represents a specific physiological process for the study of the peculiarities of the mechanism of spermatogenesis and for perceiving the basic evolution of all developmental processes, since it involves specific molecular processes of somatic and sex cells. Spermatogenesis generates spermatozoa from spermatogonal stem cells through several stages and comprises spermatocytogenesis, meiosis and spermiogenesis with the continuous unfolding of molecular events of mitosis, meiosis and epigenetic dynamic changes at the morphological and molecular level. Spermatogenesis establishes some dynamic changes by overlapping the functions of different types of cells and is maintained by different physiological factors impacting testicular morphofunction. The existing overlaps complicate the conclusive elucidation of the individual roles of different somatic and germ cells in the self-renewal, proliferation and apoptosis of spermatogonial stem cells and create difficulties in understanding the contribution of distinct signaling molecules during spermatogenesis. Several factors, compounds secreted by all somatic cells, including Sertoli cells, peritubular myoid cells and Leydig cells are involved in the regulation and development of spermatogenesis, but the mechanisms by which these factors interact in somatic and germ cells are largely unknown and a comprehensive study of these cells is needed.
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    Sănătatea societății contemporane – problemă globală ce amenință viitorul civilizației. Rezolvarea problemei sănătății e posibilă doar prin dezvoltarea sanocreatologiei
    (Editura USM, 2024) Furdui, Teodor; Ciochină, Valentina; Furdui, Vlada; Vudu, Stela; Priseajniuc, Victoria; Glijin, Aliona; Balan, Ion; Vrabie, Valeria; Jitari, Iurii
    The paper examines the problem of somato-vegetative health of the contemporary population as one of the most important, which determines the future of civilization. The analysis of the bibliographic literature indicates the insufficient study of the systems and mechanisms that determine the formation,maintenance and deterioration of health, as a specific phenomenon that ensures the human vitality and daily activity. Based on the literature and special own studies, the definition of somatovegetative health, physiological and psychical indicators of health identification, determinants of the formation and deterioration of health were developed and argued. Evidence is provided in support of the statement of the way to solve the health problem - the development of sanocreatology, science about creating,maintaining, strengthening health of the human organism and preventing its premature deterioration.
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    Factorii alimentari sano- și dissanogeni, comuni pentru microbiocenoza intestinală și sistemul reproducător masculin
    (Editura USM, 2024) Leorda, Ana; Furdui, Vlada; Tolstenco, Dorina
    Diet composition is the most important extrinsic factor influencing individual differences in intestinal microbiota, and nutritional factors play a key role in determining reproductive health and can positively or negatively influence human fertility. Thus, extrinsic factors with a sanogenic character are of particular importance, which on the one hand have a positive impact on MI, and this in turn on the reproductive system, and on the other hand directly influence this system. The healthy and unhealthy aspects of the food ration with a common impact on the intestinal microbiocenosis and the reproductive system have been identified, since understanding the factors that contribute to affecting MI and decreasing male fertility is crucial for minimizing their impact. The role of intermittent fasting in maintaining the health of these two systems was also elucidated, as well as the effects of alcohol depending on the dose used.
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    The relationship of the intestinal microflora and reproductive health (Review)
    (Editura USM, 2024) Furdui, Vlada; Ciobanu, Elena; Leorda, Ana; Balan, Ion
    În prezent, există o creștere pe scară largă a interesului pentru microflora intestinală și impactul acesteia asupra sănătății și bolilor umane. Acest articol prezintă sinteză narativă privind interrelația dintre microbiomul intestinal și sănătatea reproductivă. Sunt studiate atât patologiile sistemului de reproducere feminin asociate cu disbioza intestinală, cât și relația dintre microbiota intestinală și funcția de reproducere a bărbaților. Cercetările viitoare ar trebui să se orienteze pe identificarea mecanismelor moleculare care stau la baza relației cauzale dintre microbiota intestinală și sănătatea reproducerii.
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    INFLUIENȚA EXTRACTULUI DE POLIFENOLI DIN NUCILE VERZI ASUPRA METABOLISMULUI GLUTATIONULUI DIN SERIUL SANGUIN AL COCOȘILOR
    (CEP USM, 2024) Roșca, Nicolae; Balan, Ion; Buzan, Vladimir; Balacci, Sergiu; Furdui, Vlada; Mereută, Ion; Osipciuc, Galina; Crețu, Roman; Bacu, Gheorghii
    In this paper, the influence of polyphenol extract from green walnuts on glutathione metabo lism in the blood serum of breeding roosters was studied. To achieve this purpose, hydroalcoholic extract from green walnuts was used, with a total antioxidant activity of 548,37 mg gallic acid equivalent/100 gr. For the study were used two batches of roosters, of five animals in each batch, experimental and control. As a result of the research on the influence of metabolism, changes were obtained in the content of SH-groups, G-TP, G-S-T, as well as amino acids, which are part of the glutathione composition and which were studied in different biological fluids and repro ductive cells. The basic mechanism of the central role of thiol-mediated redox control in cellular metabolism is the ability of thiol groups to reversibly change their redox state with subsequent changes in the conformational, catalytic or regulatory functions of the protein.