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    SINTEZA 4-(2-PIRIDIL)TIOSEMICARBAZIDEI ŞI A UNOR 4-(2-PIRIDIL) TIOSEMICARBAZONE ŞI ACTIVITATEA ANTIPROLIFERATIVĂ A CELULELOR LEUCEMICE HL-60
    (CEP USM, 2012) Căpăţînă, Tatiana; Gulea, Aurelian; Barbă, Alic
    In the present work it was proposed a new method of synthesis of 4-(2-pyridyl) thiosemicarbazide and were synthesized eight 4-(2-pyridyl) thiosemicarbazons by the known method. The identity and purity of organic obtained compounds were demonstrated by chromatography, melting point, as well as by 13C and 1H NMR spectra. The synthesized substances were tested, studying the antiproliferative activity of HL-60 leukemia cells. The properties of compounds represent an interest for medicine in terms of expanding of an arsenal of inhibitors in human leukemia HL-60 myeloid, thiosemicarbazone manifest comparable activity with the one of such drugs as doxorubicin (Doxo) used in medicine for leukemia treatment.
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    ACTIVIZAREA REACTIVILOR ORGANICI PRIN COORDINARE
    (Academia de Ştiinţe a Moldovei, 2013) Revenco, Mihai
    The paper represents a review of the publications devoted to the studies of the infl uence of the thiosemicarbazones and their analogues coordination on the reactivity of the ligands. There are discussed the ways of activation of every atoms from the thiosemicarbazide fragment, highlighted the types of the observed reactions where the activated atoms are involved, and the new transformations, which have not been described previously. The observed effects were putted in use for elaboration of new methods of organic fi ne syntheses, for obtaining substances for biological applications, new materials including molecular magnets, catalysts, analytical reagents for determination, preconcentration and separation of metal ions.