2. Articole

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    Exploring the antioxidant activity of 1-(piperidin-1-yl) propane-1,2-dione 4-phenylthiosemicarbazone and 3d metal coordination compounds with this ligand [Articol]
    (CEP USM, 2024) Graur, Ianina; Maxim, Mihail; Graur, Vasilii; Tsapkov, Victor; Gulea, Aurelian; Garbuz, Olga
    The new 1-(piperidin-1-yl)propane-1,2-dione 4-phenylthiosemicarbazone (HL) and its 7 coordination compounds [Cu(L)X] (X = Br- (I); Cl- (II); NO3 - (III); CH3COO- (IV); Cl2CHCOO- (V)), [Co(L)2]NO3 (VI), [Fe(L)2]NO3 (VII) have been synthesized and characterized by elemental analysis, FTIR, 1H, 13C NMR spectra and molar electric conductibility. For the obtained compounds it was studied the antioxidant activity towards ABTS•+ radical cation. Uncoordinated 4-phenylthiosemicarbazone HL is the most active one with IC50 14.1 μM. Its activity is higher than that of Trolox which is used in medicine as an antioxidant. Among all the synthesized coordination compounds, the iron(III) complex VII showed the greatest activity. The antioxidant activity of metal complexes is influenced by the anion and the nature of the central metal atom.
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    Funcționalizarea chitosanului cu polifenoli și utilizarea acestor complecși în inhibiția N-nitrozaminelor formate la nitrozarea medicamentelor [Articol]
    (CEP USM, 2020) Ceacîru, Cristina
    In this paper, an extensive study was performed on the processes of nitrosation of drugs, which leads to the formation of N-nitrosamines (NNA), which 80% are carcinogenic. The process of nitrosation of antibiotics with nitrites ions and NNA formation was studied depending on the nature of the studied drug and depending on the pH. Chitosan derivatives functionalized with polyphenols and thiosemicarbazides were synthesized to inhibit nitrosis. For the structural analysis of the obtained copolymers were used the methods: UV-VIS, IR, 1H-NMR. The antioxidant activity of the copolymers obtained was determined by the DPPH method.