2. Articole

Permanent URI for this collectionhttps://msuir.usm.md/handle/123456789/46

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Author: search.filters.author.Zosim, LilianaHas files: Yes

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    PROCEDEU INOVATIV DE SPORIRE A CONŢINUTULUI DE POLIZAHARIDE ACIDE LA CIANOBACTERIA SPIRULINA PLATENSIS
    (2019) Zosim, Liliana; Bulimaga, Valentina; Rudic, Valeriu; Gulea, Aurelian; Țapcov, Victor
    A fost elaborat un procedeu inovativ de sporire a conţinutului de polizaharide acide la cianobacteria Spirulina platensis, cultivată în prezenţa compusului coordinativ (PPh4)2[Mo2O2S2(IDA)2].2,8H2O. A fost propusă schema integrală de realizare a procedeului de cultivare a spirulinei şi de obţinere a polizaharidelor din biomasă.
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    PROCEDEE DE OBŢINERE A BIOMASEI DE SPIRULINĂ CU CONŢINUT SPORIT DE CUPRU LEGAT ORGANIC
    (2013) Batîr, Ludmila; Zosim, Liliana; Elenciuc, Daniela; Țapcov, Victor; Gulea, Aurelian; Rudic, Valeriu
    În prezentul articol este descrisă elaborarea a două procedee de obţinere a biomasei de spirulină cu conţinut sporit de cupru legat cu compuşi organici componenţi ai biomasei (proteine, oligopeptide, aminoacizi, lipide, glucide), utilizându-se în calitate de reglatori compuşii coordinativi ai Cu(II).
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    SCREENING OF BIOLOGICAL PROPERTIES OF MOV2O2S2- AND MOV2O4-BASED COORDINATION COMPLEXES: INVESTIGATION OF ANTIBACTERIAL, ANTIFUNGAL, ANTIOXIDATIVE AND ANTITUMORAL ACTIVITIES VERSUS GROWING OF SPIRULINA PLATENSIS BIOMASS
    (Elsevier, 2021) Gulea, Aurelian; Fuior, Arcadie; Garbuz, Olga; Bulimaga, Valentina; Zosim, Liliana; Cebotari, Diana; Toderaș, Ion
    This paper deals with the biological potential of coordination compounds based on binuclear core [MoV2O2E2]2+ (E = O or S) coordinated with commercially available ligands such as oxalates (Ox2−), L-cysteine (L-cys2−), L-histidine (L-his−), Iminodiacetate (IDA2−), Nitrilotriacetate (HNTA2− or NTA3−) or ethylenediamine tetraacetate (EDTA4−) by means of various in vitro assays in a screening approach. Results suggest that the obtained complexes show weak antibacterial and antifungal properties while not being cytotoxic on cancerous and mammalian cells. In contrast, [Mo2O2E2(L-cys)2]2− complexes stand out as powerful antioxidant, whereas [Mo2O2E2(EDTA)]2− associating tetraphenylphosphonium counter-cations display strong antibiotic activity. Finally, some complexes have evidenced a positive activity towards the growing of spirulina platensis together with a modification of the proportions of biological components inside the cells. These findings reveal promising bioactivity of the bridged binuclear Mo(+V) cores inside complexes and encourage further research for new highly active yet non-toxic molecules for biological and biomedical applications.