2. Articole

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Author: search.filters.author.Rusnac, RomanSubject: search.filters.subject.thiosemicarbazone

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    Synthesis and biotechnological study of ethyl 2-((E)-2-((E) phenylallylidene) hydrazinecarbothioamido) acetate [Articol]
    (CEP USM, 2024) Ciursin, Andrei; Trofim, Alina; Rusnac, Roman
    The quality and length of human life is directly related to the development of medicine, in particular drugs. The modern world is constantly in the process of developing new, more effective drugs. Thiosemicarbazones may be one of the promising solutions. Despite their outstanding biological activities, many of them are toxic and cannot be used as medicines. The solution may be thiosemicarbazones, which are based on natural substances. This is expected to signifcantly reduce toxicity without impairing the biological activity of the substances. In this regard, for this work, a thiosemicarbazone was synthesized, which is based on two natural substances, glycine and cinnamaldehyde. To test the toxicity of this substance, some strains of cyanobacteria were used in this article. In addition to the lack of toxicity to these microorganisms, the synthesized thiosemicarbazone had a biostimulating effect.
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    Synthesis, characterization, andbiological properties of the copper(II) complexes with novellig and: N-[4-({2-[1-(pyridin2-yl)ethylidene] hydrazinecarbothioyl}amino) phenyl] acetamide [Articol]
    (2023) Rusnac, Roman; Garbuz, Olga; Ciumacov, Iurie; Țapcov, Victor; Hureau, Christelle; Istrati, Dorin; Gulea, Aurelian
    For the first time, a thiosemicarbazone-type ligand containing a paracetamol structural unit was synthesized. Five new coordination compounds based on copper(II) salts: [Cu(L)CH3COO] (1), [{Cu(L)Cl}2]·H2O (2), [Cu(L)H2O·DMF]NO3 (3), [Cu(L)Br] (4), [Cu(L)H2O]ClO4 (5), were obtained, where HL is N-[4-({2-[1-(pyridin-2-yl)ethylidene]hydrazinecarbothioyl}amino)phenyl]acetamide. The new HL was characterized by NMR, FTIR, spectroscopy, and X-ray crystallography. All copper(II) coordination compounds were characterized by elemental analysis, FTIR, EPR spectroscopy, and molar electrical conductivity. Furthermore, single crystal X-ray diffraction analysis elucidated the structures of thiosemicarbazone HL as well as complexes 1–3. All compounds were tested for antimicrobial, antifungal, and antioxidant activities, and their toxicity to Daphnia magna was studied. Biological evaluation has revealed that most of the synthesized compounds demonstrate promising antibacterial, antifungal, and antioxidant activities. In many cases, their antibacterial/antifungal activity is comparable to that of certain drugs used in medicine for these purposes, and in some cases, even surpasses them. HL and complexes 2–5 exhibit antioxidant activity that surpasses that of Trolox. Furthermore, HL and complex 2 display virtually no toxicity to D. magna.