2. Articole

Permanent URI for this collectionhttps://msuir.usm.md/handle/123456789/46

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Author: search.filters.author.Graur, VasiliiSubject: search.filters.subject.activitate antitumorală

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    Synthesis, characterization and biological activity of copper(ii), nickel(II), cobalt(III) and iron(III) coordination compounds with 2-hydroxy-3-methoxybenzaldehyde n(4)-allyl-s-methylisothiosemicarbazone [Articol]
    (CEP USM, 2018) Usataia, Irina; Graur, Vasilii; Tsapcov, Victor; Gulea, Aurelian
    The paper presents the synthesis of the 2-hydroxy-3-methoxybenzaldehyde N(4)-allyl-S-methylisothiosemicarbazone (HL) and seven coordination compounds of copper, nickel, cobalt and iron with this ligand. The new obtained compounds were studied using IR, 1H and 13C NMR spectroscopy, elemental analysis, molar electric conductibility and magnetic susceptibility. The in vitro antiproliferative activity of the HL and synthesized coordination compounds was screened on HeLa cancer cells and normal MDCK cells. The isothiosemicarbazone HL shows better anticancer activity towards HeLa cancer cells than doxorubicin that is used in medical practice and it also practically does not affect the growth and proliferation of normal cells. Moreover, it manifests high antioxidant activity towards ABTS•+ radical cation that exceeds the activity of trolox.
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    Synthesis and antitumor activity of copper, nickel and cobalt coordination compounds with 1-(2-hydroxyphenyl)ethanone n(4)-allyl-3-thiosemicarbazone [Articol]
    (CEP USM, 2015) Graur, Vasilii; Savcin Serghei; Tsapkov Victor; Gulea, Aurelian
    The paper presents the synthesis of the ligand 1-(2-hydroxyphenyl)ethanone N(4)-allyl-3-thiosemicarbazone (H2 L) and six coordination compounds of copper, nickel and cobalt with this ligand. The structure of thiosemicarbazone H2 L was studied using 1 H and 13 С NMR spectroscopy. The synthesized coordination compounds were studied using elemental analysis, gravimetric analysis of water content, molar conductivity, and magnetochemistry. For H2 L the antitumor activity towards human leukemia HL-60 cells and cervical cancer HeLa cells was determined. It was established that the substitution of hydrogen atom with methyl group in the azomethinic fragment leads to the growth of antitumor activity.