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    SYNTHESIS OF NEW HOMODRIMANE SESQUITERPENOIDS CONTAINING DIAZINE, 1,2,4-TRIAZOLE AND CARBAZOLE RINGS
    (2018) Duca, Gheorghe; Aricu, Aculina; Lungu, Lungu; Tenu, Nadejda; Ciocarlan, Alexandru; Gutu, Yacob; Dragalin, Ion; Barba, Alic
    The present paper reports on six step synthesis of 11-homodrim-6,8-dien-12-oic acid N-substituted amides containing diazine, 1,2,4-triazole and carbazole rings based on commercially available sclareolide. The mentioned compounds were prepared for the first time by interaction of the generated in situ acyl chloride with some heterocyclic amines: 2- and 4-aminopyrimidine, 2-aminopyrazine, 5-amino-1,2,4-triazole and N-aminocarbazole. Their structures were fully elucidated by elemental and spectral analyses (IR, 1H and 13C NMR).