Sisteme de reglare a homeostaziei intestinale în condiţii de inactivitate fizică şi psihică [Articol]

Abstract

Experts suggest that mortality attributed to non-communicable diseases will increase to 52 million by 2030, and insufficient levels of physical activity bear a large part of the burden of these diseases. Physical inactivity, which affects intestinal motility, peristalsis, blood supply, as well as the immune system, also has a negative impact on the intestinal microbiota, le- ading to dysbacteriosis and changes in the composition of microorganisms. Targeted modulation of the gut microbiota offers opportunities for the development of therapeutic tools to optimize (in athletes) or restore muscle function (in patients with diseases affecting skeletal muscles) due to hypoactivity. A pronounced negative impact on intestinal homeostasis is mental inactivity, asso- ciated with a sedentary lifestyle and psychological stress.