The metabolic connection between diabetes mellitus and autoimmune hypothyroidism
dc.contributor.author | Kuchkarova, Lubov | en |
dc.contributor.author | Kayumov, Khasan | en |
dc.contributor.author | Berdiyorova, Sevara | en |
dc.contributor.author | Achilov, Rashid | en |
dc.contributor.author | Murtazaeva, Nurshat | en |
dc.contributor.author | Jurakulov, Shokhlakhon | en |
dc.date.accessioned | 2025-02-03T08:50:20Z | |
dc.date.issued | 2024 | |
dc.description.abstract | It is supposed that there is a connection between diabetes mellitus (DM) and autoimmune hypothyroidism (AIH). The aim of this study was to compare some biochemical blood parameters in experimental DM and AIH. The experiments were carried out on outbred white rats. DM was induced by feeding animals with a high-fat diet and a single injection of streptozotocin (35 mg/kg). AIH was induced by three subcutaneous injections of thyroglobulin(100μ/rat) and Freund's adjuvant. For the first injection complete adjuvant, for the second and third treatments, incomplete adjuvant was used on the sixth and seventh days after the first injection. Results show that level of insulin does not change but the level of thyroxine decreases slightly in diabetic rats. In rats with AIH the insulin level was sharply increase, but thyroxine level sharply decreased. Almost all blood parameters in rats with DM and AIH (some organic metabolites, activity of enzymes) were changed unidirectional. Analogical blood parameters shift in both diseases shows the metabolic ways of both autoimmune diseases intersect. This phenomenon should be taken in attention to understand the etiology of DM and AIH. | en |
dc.description.provenance | Submitted by faureanu tanea (erika.bcu@gmail.com) on 2025-02-03T08:50:20Z No. of bitstreams: 1 30_Kuchkarova Lubov.pdf: 392181 bytes, checksum: 1d15a75b63340b5467bdbf44b0fbe054 (MD5) | en |
dc.description.provenance | Made available in DSpace on 2025-02-03T08:50:20Z (GMT). No. of bitstreams: 1 30_Kuchkarova Lubov.pdf: 392181 bytes, checksum: 1d15a75b63340b5467bdbf44b0fbe054 (MD5) Previous issue date: 2024 | en |
dc.identifier.citation | KUCHKAROVA, Lubov; Khasan KAYUMOV; Sevara BERDIYOROVA; ACHILOV Rashid; Nurshat MURTAZAEVA and Shokhlakhon JURAKULOV. The metabolic connection between diabetes mellitus and autoimmune hypothyroidism. In: Fiziologia şi sănătatea: materialele congresului VIII al fiziologilor din Republica Moldova cu participare internaţională, 14-15 noiembrie 2024. Chişinău: Editura USM, 2024, pp. 279-286. ISBN 978-9975-62-815-0; ISBN 978-9975-62-816-7 (PDF). | en |
dc.identifier.doi | https://doi.org/10.52692/cfzl2024.30 | |
dc.identifier.isbn | 978-9975-62-815-0 | |
dc.identifier.isbn | 978-9975-62-816-7 (PDF) | |
dc.identifier.uri | https://msuir.usm.md/handle/123456789/16582 | |
dc.identifier.uri | https://doi.org/10.52692/cfzl2024.30 | |
dc.language.iso | en | |
dc.publisher | Editura USM | |
dc.subject | diabetes mellitus | en |
dc.subject | autoimmune hypothyroidism | en |
dc.subject | thyroxine | en |
dc.subject | insulin | en |
dc.subject | serum biochemical parameters | en |
dc.title | The metabolic connection between diabetes mellitus and autoimmune hypothyroidism | en |
dc.type | Article |