Морфофункциональная характеристика тромбоцитов у пациентов с ожирением инфицированных COVID-19

Abstract

The COVID-19 infection causes systemic intravascular coagulopathy, with acute respiratory distress syndrome development and multiorgan failure. Platelets are blood cells that mediate hemostasis and their dysfunction can be manifested by thrombocytopenia, or hyperactivation. SARSCoV-2 causes platelets’ hyperactivation with an inflammatory cytokine releasing with a blood coagulation disorder, followed by acute severe distress syndrome and thrombocytopenia in 55% of patients. There were examined 44 patients divided according BMI: gr. 1 BMI =30-34.9 kg/m², gr. 2, BMI = 35-39.9 gr. 3 BMI >40, group 4 served a control group, consisted from COVID-19 infected patients with a normal weight. The number of platelets was reduced in 3 gr.-183±30 10³/un.l, compared to 4 gr. – 238.7±40 10³/un.l p≤0.001. Platelet index PCT was higher in 3 gr. – 0.36±0.03, p≤0.01 compared to 4 gr. – 0.27±0.01(fl). C-reactive protein level was higher as well in 3 gr.– 48.6±2.6 mg/l, compared to 4 gr. – 45.3±8 mg/l, p≤0.001. On the background of thrombocytopenia in all evaluated groups, depending on BMI, there was an increase in platelet indexes, PCT and Creactive protein level.