Получение ароматических производных класса 2Н-хромена кетализацией 1,2,4- триазолилэтанонов [Articol]

Abstract

Summary. In this work the peculiarities of the ketalization reaction of aromatic 1,2,4- triazolylethanones under conditions of aldol-croton condensation with the participation of salicylic aldehyde derivatives with substituents in the third and fifth positions are considered. In the framework of this work it was found that the presence of an ortho-para orientant in the benzene ring of the initial aldehyde increases the basicity of the hydroxyl group, which contributes to the closure of the six-membered oxygen-containing cycle, as well as the presence of an electronacceptor group in the initial triazolyl ketone also contributes to the formation кетализация,: 1,2,4-triazole and 2H-chromene, forming the central part of many biologically active natural products as well as synthetic therapeutic agents. The structure of the obtained compounds was confirmed by spectral data and elemental analysis.