Probiotic strains as systemic biological anti-inflammatory agents [Articol]
| dc.contributor.author | Borshchev, Yuri | en |
| dc.contributor.author | Burovenko, Inessa | en |
| dc.contributor.author | Borshcheva, Olga | en |
| dc.contributor.author | Protsak, Egor | en |
| dc.contributor.author | Borshchev, Viktor | en |
| dc.contributor.author | Galagudza, Mihail | en |
| dc.date.accessioned | 2025-02-04T08:57:21Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Therapeutic control of the intensity, duration, and quality of immune-inflammatory processes is fundamental to the successful treatment of most infectious and non-infectious diseases, including autoimmune disorders. The aim of this study was to investigate the anti-inflammatory potential of probiotic strains. In an experiment on male Wistar rats using a model of systemic inflammatory response syndrome (SIRS), significant reductions in key inflammatory markers such as TNF-α, IL-1, IL-12, IFN-γ, and MCP-1 were observed following the administration of a probiotic mix of L. acidophilus (LA-5) and B. animalis subsp. lactis (BB-12), as well as the isolated strain L. delbrueckii TS1-06. Improvements in myocardial functional indicators, behavioral responses, and accelerated reparative and regenerative processes were noted, suggesting the potential of these probiotic strains as candidates for therapeutic agents used as slow-acting anti-inflammatory drugs. | en |
| dc.description.provenance | Submitted by faureanu tanea (erika.bcu@gmail.com) on 2025-02-04T08:57:21Z No. of bitstreams: 1 3_Borshchev Yuri.pdf: 349604 bytes, checksum: b303a72bdee10697d2e97267b21be151 (MD5) | en |
| dc.description.provenance | Made available in DSpace on 2025-02-04T08:57:21Z (GMT). No. of bitstreams: 1 3_Borshchev Yuri.pdf: 349604 bytes, checksum: b303a72bdee10697d2e97267b21be151 (MD5) Previous issue date: 2024 | en |
| dc.description.sponsorship | This research was funded by a grant from the Russian Science Foundation (project No. 23-15-00139), https://rscf.ru/project/23-15- 00139. | en |
| dc.identifier.citation | BORSHCHEV Yuri; Inessa BUROVENKO; Olga BORSHCHEVA; Egor PROTSAK; Viktor BORSHCHEV and Mihail GALAGUDZA. Probiotic strains as systemic biological anti-inflammatory agents. In: Fiziologia şi sănătatea: materialele congresului VIII al fiziologilor din Republica Moldova cu participare internaţională, 14-15 noiembrie 2024. Chişinău: Editura USM, 2024, pp. 33-40. ISBN 978-9975-62-815-0; ISBN 978-9975-62-816-7 (PDF). Disponibil: https://doi.org/10.52692/cfzl2024.03 | en |
| dc.identifier.doi | https://doi.org/10.52692/cfzl2024.03 | |
| dc.identifier.isbn | 978-9975-62-815-0 | |
| dc.identifier.isbn | 978-9975-62-816-7 (PDF) | |
| dc.identifier.uri | https://msuir.usm.md/handle/123456789/16603 | |
| dc.identifier.uri | https://doi.org/10.52692/cfzl2024.03 | |
| dc.language.iso | en | |
| dc.publisher | Editura USM | |
| dc.subject | Probiotics | en |
| dc.subject | immunity | en |
| dc.subject | inflammation | en |
| dc.subject | cytokines | en |
| dc.title | Probiotic strains as systemic biological anti-inflammatory agents [Articol] | en |
| dc.type | Article |