Particularităţile metabolismului aminoacizilor în condiţiile influenţei factorilor extremi asupra organismului [Articol]

Abstract

The article examines the particularities of amino acid metabolism under conditions of extreme stress on the body, such as hypoxia, trauma, starvation, heatstroke, or sepsis. These states cause severe metabolic imbalances, especially through intensified protein catabolism, energy deficiency, and the accumulation of toxic metabolites. Amino acids become essential energy sources and precursors for gluconeogenesis. The role of sulfur-containing amino acids (cysteine, methionine, glutathione) is highlighted, along with their impact on immunity, redox balance, and liver and kidney function. Amino acid biomarkers can reflect metabolic dysfunctions and endogenous intoxication.