Facultatea de Biologie și Geoştiinţe / Faculty of Biology and Geosciences
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Item Физиологическое значение и методы диагностики жировой ткани у пациентов с хроническими гепатопатиями [Articol](Editura USM, 2024) Головатюк, Людмила; Лупашко, Юлианна; Березовская, ЕленаExcess body weight is a serious health problem. Adipose tissue is involved in metabolic disorders formation. White and brown adipose tissue are organs that have anatomical, functional and genetic diversity. The aim: to study the functions and physiological significance and diagnostic methods of adipose tissue in patients with chronic hepatopathies. There were examined 591 patients with chronic hepatopathies: 177 with BMI <25 (Group I), 228 with BMI 25-30 (Group II) and 186 patients with BMI >30 kg/m2 (Group III). In group I, BMI was 23.20 ± 0.19 kg/m², and waist circumference was 89.62 ± 0.73 cm; in group II, these indicators were: 27.62 ± 0.12 and 99.32 ± 0.61 respectively, and in group III: 34.21 ± 0.32 and 112.32 ± 0.82, respectively. The highest percentage of body fat and visceral fat indexes were observed in patients with BMI >30 kg/m2. Diagnosis of metabolic disorders in patients with chronic hepatopathies should include BMI and waist circumference evaluation, and, if necessary, supplemented by determining the percentage of fat and visceral fat data using bioimpedance analysis.Item Морфофункциональная характеристика тромбоцитов у пациентов с ожирением инфицированных COVID-19 [Articol](Editura USM, 2024) Гельмич, Татьяна; Лупашко, Юлианна; Березовская, Елена; Бурда, Татьяна; Оуш, МарианаThe COVID-19 infection causes systemic intravascular coagulopathy, with acute respiratory distress syndrome development and multiorgan failure. Platelets are blood cells that mediate hemostasis and their dysfunction can be manifested by thrombocytopenia, or hyperactivation. SARSCoV-2 causes platelets’ hyperactivation with an inflammatory cytokine releasing with a blood coagulation disorder, followed by acute severe distress syndrome and thrombocytopenia in 55% of patients. There were examined 44 patients divided according BMI: gr. 1 BMI =30-34.9 kg/m², gr. 2, BMI = 35-39.9 gr. 3 BMI >40, group 4 served a control group, consisted from COVID-19 infected patients with a normal weight. The number of platelets was reduced in 3 gr.-183±30 10³/un.l, compared to 4 gr. – 238.7±40 10³/un.l p≤0.001. Platelet index PCT was higher in 3 gr. – 0.36±0.03, p≤0.01 compared to 4 gr. – 0.27±0.01(fl). C-reactive protein level was higher as well in 3 gr.– 48.6±2.6 mg/l, compared to 4 gr. – 45.3±8 mg/l, p≤0.001. On the background of thrombocytopenia in all evaluated groups, depending on BMI, there was an increase in platelet indexes, PCT and Creactive protein level.Item Использование новых технологий в оценке питания больных с хроническими заболеваниями печени [Articol](CEP USM, 2024) Головатюк, Людмила; Лупашко, Юлиана; Березовская, ЕленаThere is a need for simple, accurate and non-invasive methods for assessing body composition, such as bioelectrical impedance analysis (BIa), 282 patients with chronic liver pathology were examined, 75 patients with chronic viral hepatitis (HVC group), 96 patients with hepatic steatosis (sH group), 111 patients with liver cirrhosis (lC group). BIa indicators: BMI, percentage of body fat (PBF), indicator of the proportion of visceral fat (PVF) and total cholesterol, HDl, lDl and triglycerides (TG) in serum were determined. BMI in the sH group - 30.29±0.50, in the HVC group - 28.13±0.65, in the lC group - 22.69±0.16 kg/m². PBF: 36.02±1.06 (sH group), 34.16±1.33 (HVC group), 22.90±0.85% (lC group). lDl: 3.73±0.13 (sH group), 3.02±0.14 (HVC group), 2.35±0.15 mmol/l (lC group). TG: 1.87±0.11 (sH group), 1.48±0.22 (HVC group), 0.80±0.04 mmol/l (lC group). The highest rates of both biochemical and BIa are observed in the sH group, and the lowest in the lC group. To study lipid metabolism of patients with chronic liver disease BIa can be recommended.Item ИСПОЛЬЗОВАНИЕ ПСИХОМЕТРИЧЕСКИХ МЕТОДОВ ДЛЯ ДИАГНОСТИКИ ЭМОЦИОНАЛЬНОГО СТАТУСА У ПАЦИЕНТОВ С ХРОНИЧЕСКИМИ ГЕПАТОПАТИЯМИ(CEP USM, 2021-04-22) Березовская, Елена; Думбрава, Влада-ТатьянаThe article presents a theoretical analysis of scientific literature on the co-morbidity of depression and chronic hepatopathy. It highlights the problem of growing prevalence of liver pathology in both Republic of Moldova and worldwide. A systematization attempt of published psychometric and clinical methods for diagnosing depressive disorders in patients with chronic hepatopathy has been carried out as well as an elaboration of a possible way of classification of the methods examined. An algorithm has been created for applying a certain technique, depending on goals and possibilities of study of depression in patients with chronic hepatopathy. The article stresses the need for a systematic methodologically justified approach to the diagnosis of depressive disorders of the patients.