Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology

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Start date: 2018End date: 2018

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    Концепция эколого-энергоэффективности процессов обработки органических отходов [Articol]
    (2018) Ковалёв, Виктор; Унгуряну, Дмитрий; Ковалёва, Ольга; Полещук, Г.
    Экологические проблемы являются жизненно важными для человечества. Не в последнюю очередь это касается сбросов плохо очищенных сточных вод, твердых отходов, накапливающихся мусорных отвалов и связанных с ними нестерпимыми запахами в воздушных выбросах от них. В статье предложена концепция интегрированной обработки осадков сточных вод совместно с посторонними для очистных станций отходами: растительными, агропромышленного производства, которые предварительно подвергаются измельчению, гидролизу и силосованию, смысл которой заключается в трансформировании очистных станций канализации в независимые в энергетическом и экономическом отношении предприятия за счет утилизации биогаза и вторичных продуктов в виде удобрений и протеинового сырья, с генеральной тенденцией к безотходному производству. Для токсических осадков и органических отходов предлагаются альтернативные технические решения использования и ликвидации, как то сжигание, жидкофазное окисление, газификация, пиролиз и термолиз, грибковая технология, производство биоразлагаемого пластика, продолжительное складирование в хранилищах с целью гигиенизации, захоронение и т.п.
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    Synthesis, characterization, crystal structure of novel Cu (II), Co (III), Fe (III) and Cr (III) complexes with 2-hydroxybenzaldehyde-4-allyl-S-methylisothiosemicarbazone: Antimicrobial, antioxidant and in vitro antiproliferative activity [Articol]
    (2018) Pahonțu, Elena; Usataia, Irina; Graur, Vasilii; Ciumacov, Iurie; Petrenko, Peter; Gudumac, Valentin; Gulea, Aurelian
    2-Hydroxybenzaldehyde-4-allyl-S-methylisothiosemicarbazone and Cu (II), Co (III), Fe (III) and Cr (III) complexes were synthesized and characterized. The new obtained compounds were investigated by elemental analysis, magnetic susceptibility measurements, molar electric conductivity, IR, 1H NMR, 13C NMR, UV–Vis spectroscopy. In addition, the structure of the ligand and six complexes has been determined by single-crystal X-ray diffraction analysis. The Cu atom in complex 3 is penta-coordinated in a distorted square–pyramidal coordination geometry, while the metals in complexes 5–9 are in a distorted octahedral environment. For all compounds the antimicrobial activity was studied on a series of standard strains, such as Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, Salmonella abony and Candida albicans. The in vitro antiproliferative activity of the ligand and complexes was screened on human leukemia HL-60 cells, human cervical epithelial HeLa cells, human epithelial pancreatic adenocarcinoma BxPC-3 cells, human muscle rhabdomyosarcoma spindle and large multinucleated RD cells. The primary screening on a wider series of cancer cells showed that copper coordination compound 2 manifests high activity towards HeLa, BxPC-3 and RD cancer cells, which is three–six times higher than the activity of doxorubicin. The selectivity index that is the ratio between the IC50 value for the normal MDCK cells and IC50 values for the cancer cells varies in the range 2.44–21.17. This index is 5.5–11 times higher for the copper coordination compound 2 than for the doxorubicin. Cr (III), Fe (III) and Co (III) coordination compounds 6–9 manifest high antioxidant activity towards ABTS•+ that exceeds 47–67 times the activity of Trolox.
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    Metodă nouă de apreciere a toxicităţii substanţelor chimice [Articol]
    (Imprimt Plus, 2018-09-21) Toderaș, Ion; Gulea, Aurelian; Gudumac, Valentin; Roșcov, Elena; Garbuz, Olga
    We developed a new invention that relates to method for assessing the toxicity of chemical substances.The method of the invention includes the preparation of the culture of Paramecium caudatum, adding to the samples investigated to test chemicals in various concentrations, incubating the sample to be studied and control the addition of colourant 3-amino-7-dimethylamino-2-methylphenazine hydrochloride, incubation with subsequent addition of solution of formalin, centrifuging the sample, removing the supernatant, adding the solution of hydroxide of sodium, determine the absorbance using a spectrophotometer, followed by calculating the percentage of paramecii viability and determine the lethal concentration (LC50) at the same time as the value of the concentration LC50 is small, the toxicity of the tested substance is higher.
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    Стимуляция сперматогенеза у петухов с приминением двухводного металлокомплекса цинка с селенистой кислотой [Articol]
    (Centrul editorial UASM, 2018-09-14) Борончук, Георгий; Гуля, Аурелиан; Цуркану, Штефан; Балан, Ион; Рошка, Николай; Казакова, Юлия; Букарчук, Л.Г.; Дубаларь, А.А.; Фёдоров, Николай
    The aim of the study: to study influens of metal complex that consists from zinc dehidrate and selenic acid, on rooster’s spermatogenesis. It has bun proven that this stimulator: this stimulator influences in a coordinative manner on the spermatogenesis of reproductive functions of rooster’s assuring the maintenance and increasing of sanogenic index of spermatogenesis – the concentration of spermatozoa by 62% and content of spermatozoa in ejaculate by 37% compared with control, which indicates the synergy of zinc with selenium. Spermatosthimulatory effect of the studied coordination compound can be caused by its action on the spermatogenic epithelium of the reproductive system of cocks.
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    Стимуляция сперматогенеза петухов четырёхводным метоллокомплексом цинка с трихлоруксусной кислотой [Articol]
    (Centrul editorial UASM, 2018-09-14) Борончук, Георгий; Гуля, Аурелиан; Цуркану, Штефан; Балан, Ион; Рошка, Николай; Казакова, Юлия; Букарчук, Л.Г.; Быркэ, Мария; Бузан, Владимир; Мереуца, Ион
    Was shown spermatogenic effect of the product of a four-water zinc metal complex with trichloracetic acid when administered orally to experimental cocks. As a result, an increase in the lifetime of gametes at 37 °C by 50,79% was established, and their concentration in the seed was increased by 34,75% compared with the pre-experimental period.
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    Synthesis, characterization and toxicity evaluation of Cu(II), Mn(II), Co(II), Ni(II), Pd(II) complexes with ligand derived from hydrazinecarbothioamide [Articol]
    (2018) Pahontu, Elena; Socea, Laura Ileana; Barbuceanu, Ștefania Felicia; Ilieș, Diana Carolina; Badea, Mihaela; Olaru, Octavian Tudorel; Gulea, Aurelian; Socea, Bogdan; Bratu, Ovidiu
    New copper(II), manganese(II), cobalt(II), nickel(II) and palladium(II) complexes, [Cu(L)(X)(H2O)] [X= OAc- (1), Cl- (3), ClO4 - (4)], [M(L)2(H2O)2] [M= Cu2+(2), Mn2+(5)], [M(L)(OAc)(H2O)] [M= Co2+(6), Pd2+(8)], [Ni(L)(OAc)] (7) were synthesized with 2-(5H-dibenzo [a,d][7] annulen-5-ylacetyl)-N-(4-chlorophenyl) hydrazinecarbothioamide (HL). All the metal complexes have been characterized by different physico-chemical techniques like molar conductivity, magnetic susceptibility measurements, electronic and infrared spectral studies, elemental and thermal analysis. The toxicity of newly synthesized compounds was evaluated using the Daphnia magna bioassay.
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    Synthesis and antiproliferative activity of 5-pyrazolone derivatives and there Cu(II), Ni(II), Co(II) and V(V) complexes [Articol]
    (2018) Pahontu, Elena-Mihaela; Poirier, Donald; Gulea, Aurelian
    Complex combinations of Cu(II), Ni(II), Co(II) and V(V) with thiosemicarbazone derivatives of 1-phenyl3-methyl-4-benzoyl-5-pyrazolone-4-R-thiosemicarbazone (where R = CH3, C2H5, C6H5, C5H5N) were synthesized. The characterization of the newly formed compounds was done by 1H NMR, 13C NMR, IR, UV–Vis spectroscopy, elemental analysis, molar electric conductibility, magnetic susceptibility measurements and thermal analysis. For the copper(II) complexes metal–ligand bonding parameters have been evaluated from the EPR spectra. In addition, the structures of the ligands ( HL1-3) and its copper(II) (1, 6, 8, 12), nickel(II) (3, 13) and vanadium(V) (9) complexes were determined by single-crystal X-ray diffraction. The composition of the coordination polyhedron of the central atom in complexes is different. The complexes and ligands were tested for their in vitro antiproliferative activity on human leukemia HL-60. Antiproliferative activity of copper(II) complexes (1, 2, 5 - 8, 11, 12, 15, 16 ) at 10 μM is similar to doxorubicin, used in medical practice as antileukemia drug. The IC50 values were found to be 0.24 μM for complex 2, 0.3 μM for complex 6 and 0.36 μM for complex 11 reveal the potential antiproliferative of these compounds.
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    Crystal Structure of the Acetic Acid Solvate of N-(Prop-2-En-1-Yl)-2-(Pyrid-2-Ylmethylidene) Hydrazinecarboselenoamide [Articol]
    (2018) Ciumacov, Iurie; Petrenko, Peter A.; Graur, Vasilii; Țapcov, Victor; Gulea, Aurelian
    The crystal structure of the acetic acid solvate of N-(prop-2-en-1-yl)-2-(pyrid-2- ylmethylidene)hydrazinecarboselenoamide (I) is determined. The asymmetric unit of the unit cell in its crystal structure contains a molecule of I and an acetic acid molecule. The molecule of I is non-planar; the angle between the mean square planes of hydrazinecarboselenoamide A(Sе1N1N2N3С1C2) and prop-2-en-1-yl (С5С6C7) moieties is 82.3°. In the crystal, the acetic acid molecules link the molecules of I in endless chains along the [010] direction.
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    Synthesis and biological activity of copper(II), nickel(II) and cobalt(III) coordination compounds with 2-benzoylpyridine N(4)-allyl-S-methylisothiosemicarbazone [Articol]
    (2018) Usataia, Irina; Graur, Vasilii; Zariciuc, Elena; Garbuz, Olga; Gulea, Aurelian
    The paper presents the synthesis of the 2-benzoylpyridine N(4)-allyl-S-methylisothiosemicarbazone and five coordination compounds of copper(II), nickel(II) and cobalt(III) with this ligand. New synthesized substances were studied using IR and NMR (1H and 13C) spectroscopies, elemental analysis, molar conductivity and magnetochemical research. It was studied in vitro antimicrobial and antifungal activities against a wide range of standard strains Staphylococcus aureus (ATCC 25923), Escherihia coli (ATCC 25922), Klebsiella pneumonae and Candida albicans for synthesized substances. The study of the antiproliferative properties in vitro of the pro-ligand and complexes was tested on the human myeloid leukemia HL-60 and cervical cancer HeLa cells.
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    Influenta râului Răut asupra capacitătii de autopurificare radicalică a fluviului Nistru în perioada 2015-2017 [Articol]
    (CEP USM, 2018) Blonschi, Vladislav; Gladchi, Viorica; Bunduchi, Elena; Borodaev, Ruslan; Gherasim, Cristina