Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology

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Author: search.filters.author.Usataia, IrinaSubject: search.filters.subject.compuși coordinativi

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    COORDINATION COMPOUND AS INHIBITOR OF SUPEROXID RADICAL
    (2019) Garbuz, Olga; Pantea, Valeria; Usataia, Irina; Graur, Vasilii; Țapcov, Victor; Sardari, Veronica; Tagadiuc, Olga; Gudumac, Valentin; Gulea, Aurelian
    A fost obținut un nou compus coordinativ biologic activ, nitratul de cupru [2 - ({2 [(ethylsulfanyl) (prop-2-en-1-yl) carbononoimidooyl] -hydrazinylidene} methyl) phenolate], care face parte din clasa isotiosemicarbazidelor metalelor de tranziție.S-a stabilit că acesta exercită proprietăți anti radicalice performante la acțiunea moleculei organice cu radicalul superoxidic. Datorită acestei poroprietăți compusul obținut poate avea o potențială aplicare in medicină in calitate de inhibitor al radicalilor superoxidici in corpul uman, care poate duce la prevenirea deteriorării tesutului cellular, aterosclerozii si carcinogenezei.Compusul coordinativ sintetizat extinde arsenalul inhibitorilor de radicali superoxidici cu activitate biologică importanta.
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    SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF COPPER(II), NICKEL(II), COBALT(III) AND IRON(III) COORDINATION COMPOUNDS WITH 2-HYDROXY-3-METHOXYBENZALDEHYDE N(4)-ALLYL-S-METHYLISOTHIOSEMICARBAZONE
    (CEP USM, 2018) Usataia, Irina; Graur, Vasilii; Tsapcov, Victor; Gulea, Aurelian
    The paper presents the synthesis of the 2-hydroxy-3-methoxybenzaldehyde N(4)-allyl-S-methylisothiosemicarbazone (HL) and seven coordination compounds of copper, nickel, cobalt and iron with this ligand. The new obtained compounds were studied using IR, 1H and 13C NMR spectroscopy, elemental analysis, molar electric conductibility and magnetic susceptibility. The in vitro antiproliferative activity of the HL and synthesized coordination compounds was screened on HeLa cancer cells and normal MDCK cells. The isothiosemicarbazone HL shows better anticancer activity towards HeLa cancer cells than doxorubicin that is used in medical practice and it also practically does not affect the growth and proliferation of normal cells. Moreover, it manifests high antioxidant activity towards ABTS•+ radical cation that exceeds the activity of trolox.
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    SYNTHESIS , CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF COPPER( II), NICKEL(II), COBALT(III) AND IRON(III) CO ORDINATION COMPOUNDS WITH 1 - (2 - HYDROXYPHENYL)ETHANONE N(4) - ALLYL - S - METHYLISOTHIOSEMICARBAZONE
    (CEP USM, 2018) Usataia, Irina
    The paper presents the synthesis of the 1-(2-hydroxyphenyl)ethanone N(4)-allyl-S-methylisothiosemicarbazone (HL) and seven coordination compounds of copper , nickel , cobalt and iron with this pro - ligand. The new ly obtained compounds were inves tigated by IR, 1 H and 13 C NMR spectroscopy, elemental analysis, molar electric conductibility and magnetic susceptibility. For the synthesized compounds the antibacterial and antifungal activities in vitro were studied on a series of standard strains, such as Staphylococcus aureus (ATCC 25923), Escherihia coli (ATCC 25922), Klebsiella pneumonae and Candida albicans . The in vitro antiproliferative a ctivity of the pro - ligand and complexes was screened on Hep - 2, BxPC - 3, RD cancer cells and normal MDCK cells . I t was established that coordination compounds manifest better antiproliferative activity than the proligand.