Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology

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Author: search.filters.author.Usataia, IrinaSubject: search.filters.subject.biological activity

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    SYNTHESIS , CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF COPPER( II), NICKEL(II), COBALT(III) AND IRON(III) CO ORDINATION COMPOUNDS WITH 1 - (2 - HYDROXYPHENYL)ETHANONE N(4) - ALLYL - S - METHYLISOTHIOSEMICARBAZONE
    (CEP USM, 2018) Usataia, Irina
    The paper presents the synthesis of the 1-(2-hydroxyphenyl)ethanone N(4)-allyl-S-methylisothiosemicarbazone (HL) and seven coordination compounds of copper , nickel , cobalt and iron with this pro - ligand. The new ly obtained compounds were inves tigated by IR, 1 H and 13 C NMR spectroscopy, elemental analysis, molar electric conductibility and magnetic susceptibility. For the synthesized compounds the antibacterial and antifungal activities in vitro were studied on a series of standard strains, such as Staphylococcus aureus (ATCC 25923), Escherihia coli (ATCC 25922), Klebsiella pneumonae and Candida albicans . The in vitro antiproliferative a ctivity of the pro - ligand and complexes was screened on Hep - 2, BxPC - 3, RD cancer cells and normal MDCK cells . I t was established that coordination compounds manifest better antiproliferative activity than the proligand.
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    SYNTHESIS AND BIOLOGICAL ACTIVITY OF COPPER(II), NICKEL(II) AND COBALT(III) COORDINATION COMPOUNDS WITH 2-BENZOYLPYRIDINE N(4)-ALLYL-SMETHYLISOTHIOSEMICARBAZONE
    (2018) Usataia, Irina; Graur, Vasilii; Zariciuc, Elena; Garbuz, Olga; Gulea, Aurelian
    The paper presents the synthesis of the 2-benzoylpyridine N(4)-allyl-S-methylisothiosemicarbazone and five coordination compounds of copper(II), nickel(II) and cobalt(III) with this ligand. New synthesized substances were studied using IR and NMR (1H and 13C) spectroscopies, elemental analysis, molar conductivity and magnetochemical research. It was studied in vitro antimicrobial and antifungal activities against a wide range of standard strains Staphylococcus aureus (ATCC 25923), Escherihia coli (ATCC 25922), Klebsiella pneumonae and Candida albicans for synthesized substances. The study of the antiproliferative properties in vitro of the pro-ligand and complexes was tested on the human myeloid leukemia HL-60 and cervical cancer HeLa cells..