Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology
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Item SAVANT-CHIMIST CU RENUME MONDIAL ACADEMICIANUL AURELIAN GULEA LA 70 ANI DE LA NAŞTERE(2016) Duca, Gheorghe; Furdui, Teodor; Rudic, Valeriu; Toderaș, Ion; Lupașcu, Tudor; Chirilov, Alexandru; Ciochină, ValentinaItem TESTAREA EXPERIMENTALĂ IN VIVO A COMPUȘILOR ORGANICI COORDINATIVI(CEP USM, 2023-02-13) Roșcov, Elena; Toderaș, Ion; Gulea, AurelianExperimental testing in vivo of coordinating organic compounds. We studied the influence of coordinative compounds Li2[Mo2O4EDTA].5H2O (1) and Na2[Mo2O4EDTA].5H2O (2) on the ciliate Paramecium caudatum. It was evaluated on the numerical strength and viability, which indicated that there is no distinct cytotoxic difference of complexes (1) and (2), manifesting admissible and moderate toxicity on parameciItem METODĂ NOUĂ DE APRECIERE A TOXICITĂŢII SUBSTANŢELOR CHIMICE(Imprimt Plus, 2018-09-21) Toderaș, Ion; Gulea, Aurelian; Gudumac, Valentin; Roșcov, Elena; Garbuz, OlgaWe developed a new invention that relates to method for assessing the toxicity of chemical substances.The method of the invention includes the preparation of the culture of Paramecium caudatum, adding to the samples investigated to test chemicals in various concentrations, incubating the sample to be studied and control the addition of colourant 3-amino-7-dimethylamino-2-methylphenazine hydrochloride, incubation with subsequent addition of solution of formalin, centrifuging the sample, removing the supernatant, adding the solution of hydroxide of sodium, determine the absorbance using a spectrophotometer, followed by calculating the percentage of paramecii viability and determine the lethal concentration (LC50) at the same time as the value of the concentration LC50 is small, the toxicity of the tested substance is higher.Item EVALUATION OF THE ACTION OF SOME COORDINATION COMPOUNDS ON INFUSORIA PARAMECIUM CAUDATUM (EHRENBERG, 1833) VIABILITY(2021) Roșcov, Elena; Toderaș, Ion; Gulea, Aurelian; Floquet, Sebastien; Fuior, Arcadie; Garbuz, OlgaArticolul oferă noi perspective asupra activității biologice a sărurilor de sodiu și litiu ale complexului binuclear [Mo2O4(EDTA)]2- – un model molecular sintetic binecunoscut al centrului activ al molibdoenzimelor. Experiențele clasice cu ciliatul standard Paramecium caudatum (Ehrenberg, 1833) demonstrează un efect stimulator neașteptat asupra viabilității acestora, crescând semnificativ rata lor de reproducere la concentrații micromolare ale sării de litiu în mediul nutritiv.Item THE ANTIPROLIFERATIVE, ANTIOXIDANT ACTIVITIES AND TOXICITY OF MIXED-LIGAND AMINE-CONTAIN- ING COPPER(II) COORDINATION COMPOUNDS WITH 2-(2-HYDROXYBENZYLIDENE)-N-(PROP-2-EN-1-YL)HY- DRAZINECARBOTHIOAMIDE(2021-09-16) Garbuz, Olga; Toderaș, Ion; Ulchina, Ianina; Graur, Vasile; Railean, Nadejda; Gulea, AurelianFive compounds 2-(2-Hydroxybenzylidene)-N-(prop-2-en1-yl)hydrazinecarbothioamide (H2L), bis[μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl) phenolatoS,N,O:O] diaquadicopper (II) nitrate (1), bis [μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl)phenolato-S,N,O:O]d iimidazoldicopper(II) nitrate (2), bis[μ2-2-({2-[(prop-2en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper( II) nitrate hexahydrate (3), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl) phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds towards cancer cell lines HeLa, RD and normal cell line MDCK have been investigated. The tested compounds demonstrated high antioxidant and antiproliferative, selective activities towards cancer cells. Direct toxic evaluation of compounds was performed by Daphnia magna bioassay.Item STABILIREA PARTICULARITĂȚILOR DE ACȚIUNE A COMPUŞILOR COORDINATIVI COMPLECŞI ASUPRA CULTURII DE LABORATOR PARAMECIUM CAUDATUM(Eco-TIRAS, 2021-02-01) Toderaș, Ion; Gulea, Aurelian; Roșcov, Elena; Garbuz, Olga; Railean, NadejdaItem INFLUENCE OF SOME ORGANIC COORDINATION COMPOUNDS CONTAINING COBALT AND BISMUTH ON DEVELOPMENT MORPHO-PRODUCTIVE CHARACTERS OF THE BEE FAMILIES(CERES Publishing House, 2015-09-17) Cebotari, Valentina; Buzu, Ion; Toderaș, Ion; Gulea, Aurelian; Postolachi, Olga; Toderici, Valeriu; Gliga, OleseaThe aim of the research was to evaluate and test the influence of organic coordination compounds containing rare microelements, on the vital functions and on the development of the morpho-character of Apis mellifera bee colonies. Several experiments where conducted and was tested in feeding bees in spring (April 1 to 21) a period with poor harvest in nature, a nutritious blend of 50% sugar syrup supplement enriched with bioactive organic compound heteronuclear coordinative sulfate [tris-thiosemicarbazide cobalt (III)] [1, 2-diaminociclohexantetraacetat bismuth (III)] hexahydrate - [Co (tios) 3], [Bi (CDTA)] SO4 · 6H2O in aqueous solution with concentration of 1 mg% (hereinafter referred to as "compound + Co + Bi), which was mixed with sugar syrup in a ratio of 2: 100, and was administered directly into the food of bees and bee families where feed with the nutrient in amount of 100 ... 130 ml for every frame with bees, every 2 days for a period of three weeks. Bee colonies were formed into three lots, each lot formed from 16 families, of which: group I - control, which were fed only with sugar syrup 50%, group II - prototype, which where feed with sugar syrup by adding nutritional supplement enriched with patented "Apispir + Fe + It" (MD 477 Z 2012.09.30) and group III - experimental, which received sugar syrup enriched with supplement "compound + Co + Bi". The research results have shown that using energizing nutritional supplements enriched with biologically active substances of organic compounds coordination in bee feeding in times when there is a poor harvest in nature, helps stimulate vital functions of bee families and increase their productivity: the prolificity of queen - with 5.2 to 9.7% (P <0.001); the amount of capped brood - with 5.2 to 9.7% (P <0.001); family strenght- by 2.5 to 9.7% (P <0.1s P <0.001); disease resistance - by 2.4 to 5.0% (P <0.001); brood viability - with 1.2 to 2.2% (P <0,01s (P <0.001); the amount of accumulated bee bread in brood chamber- by 15.0 to 23.3% (P <0.001), an increased amount of wax combs - by 21.4 to 39.3% (P <0.001) and the amount of honey accumulated in the colony - with 13.9 to 25.4% (P <0.01 and P <0.001). The beneficial effect of feeding bees with biologically active nutritional supplements Apispir + Fe + + Co + Se and Bi compound denotes the fact that in the spring (March-April), a period poor in harvesting, in the area studied, in nature there is a shortage of biologically active substances, including rare microelements.Item NEW NUTRITIVE SUPPLEMENTS FOR FEEDING MELLIFERA BEES IN THE DEFICIT PERIODS OF COLLECTION IN NATURE(2017) Toderaș, Ion; Cebotari, Valentina; Ungureanu, Laurenția; Buzu, Ion; Gheorghiță, Cristina; Floquet, Sebastien; Gulea, Aurelian; Rudic, Valeriu; Fuior, ArcadieThe purpose of this paper was to test the bees feeding of aquatic microalgae biomass like Scenedesmus quadricauda, Scenedesmus Apiculatus Hortob, Oocystis borgei Snow, and elaboration of feeding procedures of bee families during the deficit harvesting periods in nature, the end of winter and early spring (February - March). The research was carried out on Apis mellifera Carpatica bee families at the experimental apiary of the Institute of Zoology of the Academy of Sciences of Moldova. At the end of February, 5 similar batches of bees were formed, with 13-15 families in each batch. Each bee family was given once, 200g in a 7:3 ratio of mixture of sugar powder with honey, the consistency of a dense gelatinous paste in disk form, a disk at each bee frame. In batch I (witness), the bees received only the nutritive paste made of sugar powder + honey; In batch II the bees received nutrient paste enriched with the nutritional supplement known as Apispir in quantity of 2 ml of solution by 10% (200 mg active substance) per 1 kg of paste; In batches III, IV and V, the bees received the food nutritive paste, enriched with the biomass of aquatic microalgae, respectively: Scenedesmus quadricauda, Scenedesmus apiculatus and Oocystis borgei Snow, in quantity of 10 ml of suspension by 2.0% concentration (200 mg dry substance) to 1 kg of paste. At 100 days from the date of feeding the bees with nutritive paste (which coincided with the first collection), at each family in the experimental batches, individually, was evaluated: the queen prolificacy, the capped brood quantity, the strength of the family, the resistance to diseases, the viability of the brood, the quantity of wax increased on the combs, the quantity of pasture and honey accumulated in the nest. The results of the research have demonstrated that feeding bee families during deficit periods of harvesting in nature with a 7: 3 ratio sugar-powder + honey, nutritional mixture, enriched with biologically active supplements from Scenedesmus quadricauda, Scenedesmus apiculatus and Oocystis borgei Snow contributes to the increase, compared to the control batch: of the prolificacy of the queens by 7.8-10.3% (td = 3.5-5.2; P <0.01-0.001); the quantity of brood - by 7.7-9.3% (td = 3.4-4.7; P <0.01-0.001); the strength of the bee family - by 7.1-9.3% (td = 3.0-3.5, P <0.01); resistance of families to diseases - by 1.8-3.8% (td = 1.6-3.6; P <0.1-0.01); viability of brood - by 1.2-1.7% (td = 2.2-2.9; P <0.05-0.01); wax production increased by 13.3-36.7% (td = 2.9-6.4; P <0.01-0.001); the quantity of bee bread accumulated in the nest - by 15.527.6% (td = 3.4- 8.4, P <0.01-0.001); the quantity of honey accumulated in the nest at the first harvest - by 28.0-38.9% (td = 7.2-9.9, P <0.001). On the basis of the researches have elaboration, new procedures of feeding bee families during the deficit periods of harvesting in the nature and obtained patents of invention (MD 1061 Y 2016.08.31, MD 1079 Y 2016.08.31, MD 1079 Y 2016.10.31).Item EXCELENŢA SA ACADEMICIANUL VALERIU RUDIC ŞI BIOR-UL(ACAD. V. RUDIC LA 70 DE ANI DE LA NAŞTERE)(2017) Furdui, Teodor; Duca, Gheorghe; Gulea, Aurelian; Toderaș, Ion; Ciochină, Valentina; Cepoi, Liliana; Chirilov, Alexandru; Codreanu, Svetlana; Miscu, VeraItem SAVANTUL DE RENUME MONDIAL ȘI BIOR-UL. ACADEMICIANUL VALERIU RUDIC LA 70 DE ANI(2017) Furdui, Teodor; Duca, Gheorghe; Toderaș, Ion; Ciochină, Valentina; Cepoi, Liliana; Chirilov, Alexandru; Codreanu, Svetlana; Miscu, Vera; Gulea, Aurelian