Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology

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Author: search.filters.author.Rusnac, AnnaSubject: search.filters.subject.synthesis

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    SINTEZA COMBINAȚIILOR COORDINATIVE NOI ALE UNOR METALE 3D ÎN BAZA N(4)-(ACETAT DE ETIL) TIOSEMICARBAZONELOR 2-FORMIL ȘI 2-ACETIL PIRIDINEI. PROPRIETĂȚI ANTIOXIDANTE
    (2022) Rusnac, Anna; Garbuz, Olga; Șova, Sergiu; Gulea, Aurelian
    The given work includes the description of methods for the synthesis of new coordinative combinations of Cu(II), Mn(II), Fe(III) Co(III), Ni(II) and Zn(II) with N(4)-(ethyl acetate) thiosemicarbazones of 2-formylpyridine and 2-acetylpyridine. The characterization of the newly synthesized compounds was carried out using 1H NMR, 13C NMR, FTIR spectroscopy, conductivity, and elemental analysis. In addition, the structures of N(4)-(ethyl acetate) thiosemicarbazide and N(4)-(ethyl acetate) thiosemicarbazone 2-acetylpyridine (HL2) were determined using single crystal X-ray diffraction. The antioxidant activity of coordinative combinations was studied and compared with that of free ligands. The most pronounced antioxidant properties are possessed by [Ni(L2)Cl], whose value of IC50=15,05 μM is three times higher than the IC50=46,76 μM of the non-coordinating ligand and about 2,5 times higher than the reference substances Rutin and Trolox.
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    SYNTHESIS, CHARACTERIZATION, ANTIOXIDANT ACTIVITY EVALUATION OF 3d METALS COMPLEXES WITH N(4)-((3)-ETHYL BENZOATE) THIOSEMICARBAZONES OF 2-FORMYL(2-ACETYL, 2-BENZOIL)PYRIDINE
    (CEP USM, 2022) Rusnac, Anna; Garbuz, Olga; Shova, Sergiu; Gulea, Aurelian
    The paper presents the synthesis of new coordination compounds of Cu(II), Mn(II), Fe(III) Co(III), Ni(II) and Zn(II) with N(4)-((3)-ethyl benzoate)thiosemicarbazones of 2-formyl pyridine derivatives obtained through the condensation of N(4)-((m)-ethyl benzoate) thiosemicarbazide with 2-pyridinecarboxaldehyde, 2-acetylpyridine and 2-benzoylpyridine. The characterization of new compounds was done by 1H NMR, 13C NMR, IR spectroscopy, conductivity and elemental analysis. In addition, the structures of the ligands (HL1,3) were determined by single-crystal X-ray diffraction. The effect of these complexes on antioxidant activity were studied and compared with those of free ligands. The best result was found to be on coordination compound [Zn(L1)Cl], with IC50 = 11.45 μM, it is better than the free ligand HL1, IC50 = 13.15 μM and is better than the substance Trolox, IC50 = 15.86 μM (it is a pronounced antioxidant taken as a control substance).
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    SINTEZA COMBINAȚIILOR COORDINATIVE ALE CUPRULUI(II) ȘI NICHELULUI(II) ÎN BAZA N(4)-(p-BENZOAT DE ETIL) TIOSEMICARBAZONELOR 5-Br (3,5-di Br) SALICILALDEHIDEI
    (CEP USM, 2021) Rusnac, Anna
    This article aims to synthesize 2 new organic substances N(4)-(p-ethyl-4-benzoate) thiosemicarbazone 5-Br (3,5-diBr) salicylaldehyde. Based on them, 15 coordination compounds of Cu (II) and Ni (II) were obtained. The organic compound was analysed by IR spectroscopy and characterized by 1H and 13C nuclear magnetic resonance (NMR). The coordination compounds were chemically characterized by elemental analysis and IR spectroscopy. On the basis of IR spectroscopy and elemental analysis showed that the ligands were coordinated to the metal tridentate ligands the sulfur-thionic atom, the azomethine nitrogen atom and the oxygen-phenolic atom. After recrystallization {Ni(HL1)NO3}·2H2O in a 1:3 binary solvent mixtures of N,N-dimethylformamide, ethanol. Single crystals have been obtained, and established the structure by X-ray analysis. Where the ligand is double deprotonated, due to the DMF which possesses basic properties and has favored its double deprotonation, coordinates to the central atom through the sulf-thionic atoms, azomethine nitrogen, oxygen-phenolic, the fourth position is occupied by oxygen from the DMF solvent molecule. The compound formed has a plane square geometry, in the outer sphere coordination compound: is a DMF, co-crystallization molecule.