Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology

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Author: search.filters.author.Popușoi, AnaSubject: search.filters.subject.chalcone

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    STUDY OF THE SYNTHESIS METHODS OF 1,3-ARYL(HETERYL)PROPENONE
    (CEP USM, 2022) Popușoi, Ana
    In this work, we refer to the study of recent specialized literature, where some syntheses methods of chalcone deri- vatives are described. These substances show a very pronounced anticancer activity, having a protective action in the cellular system. They present interest due to their biological properties, such as anti-inflammatory, antioxidant, cytotoxic and antihistamine properties, etc. These important biological properties are the basis of the current research intended to obtain them synthetically. The bibliographic data refers to the synthesis of 1,3-aryl (heteryl) propenones, which are described in several reviews. The main focus is on the synthesis methods of chalcones, which allow us to obtain pure reaction products, short reaction time and high yields. Also, synthesis methods with the use of solid-based heterogeneous catalysts are described, which, in turn, are very active, durable and more economical and can be used for three synthesis cycles, without significant loss of catalytic activity. The synthesis methods studied were: aldol and crotonic condensation, Claisen-Schmidt reaction, Suzuki reaction, coupling of alkynes with aldehydes, microwave irradiation, etc
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    INVESTIGAREA METODELOR DE SINTEZĂ PENTRU 3-(ANTRACEN-9-IL)-1-(4-IZOTIOCIANATOFENIL)-PROP-2-EN-1-ONĂ
    (CEP USM, 2016) Popușoi, Ana
    Lucrarea prezintă o descriere succintă a izotiocianatochalconelor fluorescente şi redă unele metode de obţinere a lor. În aspect mai detaliat sunt cercetate metodele de obţinere a izotiocianatochalconelor ce conţin fragmentul antracenic. Rezultate bune atestă metoda ce include condensarea 3-(4-acetilfenil)-1,1-dimetiltioureei cu antracen-9-carbaldehidă, urmată de eliminarea dimetilaminei din chalconele corespunzătoare la tratare cu anhidridă acetică sau cu clorură de acetil.