Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology

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Author: search.filters.author.Pahonțu, ElenaSubject: search.filters.subject.anticancer activity

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    COORDINATION COMPOUNDS OF COBALT, NICKEL, COPPER, AND ZINC WITH N1,N2 -BIS(PYRIDIN-2-YLMETHYLIDENE)BENZENE-1,2-DIAMINE AND ITS DERIVATIVES
    (2014) Pahonțu, Elena; Gulea, Aurelian; Poirier, Donald; Țapcov, Victor
    o-Phenylenediamine reacts with 2-formyl-, 2-acetyl-, or 2-benzoylpyridine in ethanol in the presence of cobalt, nickel, copper, or zinc chlorides to form monomeric complexes ML1-3Cl2·nH2O {M = Co, Ni, Cu, Zn; L1 = N 1,N 2-bis(pyridin-2-ymethylidene)benzene-1,2-diamine, L2 = N 1,N 2-bis(pyridin-2-ylethylidene) benzene-1,2-diamine, L3 = N 1,N 2-bis[phenyl(pyridin-2-yl)methylidene]benzene-1,2-diamine; n = 0-3}. The condensation products (L1-L3) act in the complexes as tetradentate N,N,N,N-ligands. Thermolysis of the complexes occurs in two stages: dehydration (70-95°C) and complete degradation (320-450°C). At concentrations of 10-5-10-7 M, the complexes inhibit in vitro growth and proliferation of HL-60 human promyelocytic leukemia cells.
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    COORDINATION COMPOUNDS OF COPPER AND NICKEL WITH N,N'-[4,4'-(PERFLUORO-1,4-PHENYLENE)BIS(OXY)BIS(4,1-PHENYLENE)]- BIS[2-(PYRIDIN-2-YLMETHYLIDENE)HYDRAZINECARBOTHIOAMIDE] AND ITS DERIVATIVES
    (2014) Pahonțu, Elena; Țapcov, Victor; Poirier, Donald; Gulea, Aurelian
    N,N′-[4,4′-(Perfluoro-1,4-phenylene)bis(oxy)bis(4,1-phenylene)] bis[2-(pyridin-2-ylmethylidene)-hydrazinecarbothioamide] as well as its methyl and phenyl derivatives react with copper and nickel chlorides in ethanol to form coordination compounds. In the products, the hydrazinecarbothioamides act as doubly deprotonated bridging ligands. The prepared complexes have been found to inhibit in vitro the growth and propagation of the myeloid human leukemia HL-60 cancer cells at the 10-5-10-7 mol/L concentration.
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    COORDINATION COMPOUNDS OF COBALT, NICKEL, COPPER, AND ZINC WITH N1 ,N2 -BIS(PYRIDIN-2-YLMETHYLIDENE)BENZENE-1,2-DIAMINE AND ITS DERIVATIVES
    (Pleiades Publishing Ltd., 2014) Pahonțu, Elena; Gulea, Aurelian; Poirier, D.; Tsapkov, V. I.
    о-Phenylenediamine reacts with 2-formyl-, 2-acetyl-, or 2-benzoylpyridine in ethanol in the presence of cobalt, nickel, copper, or zinc chlorides to form monomeric complexes ML1−3 Сl2·nH2O {M = Co, Ni, Cu, Zn; L1 = N1,N2 -bis(pyridin-2-ymethylidene)benzene-1,2-diamine, L2 = N1,N2-bis(pyridin-2-ylethylidene)benzene-1,2-diamine, L3 = N1,N2 -bis[phenyl(pyridin-2-yl)methylidene]benzene-1,2-diamine; n = 0–3}. The condensation products (L1−L3) act in the complexes as tetradentate N,N,N,N-ligands. Thermolysis of thecomplexes occurs in two stages: dehydration (70–95°С) and complete degradation (320–450°С). At concentrations of 10–5–10–7 M, the complexes inhibit in vitro growth and proliferation of HL-60 human promyelocytic leukemia cells.