Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology
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Item Synthesis of chitosan grafted with aminomethyl zinc phthalocyanine for photodynamic therapy [Articol](2025) Robu, Ștefan; Potlog, Tamara; Bulimestru, Ion; Lungu, Ion; Sadohina, Olga; Druța, Alexandrina; Bulmaga, Petru; Guțu, IacobThis paper reports the synthesis of a substituted aminomethyl zinc phthalocyanine (AmPcZn) and its covalent grafting onto chitosan via an ethyl chloroformate-mediated reaction. Chitosan-based copolymers containing 10%, 20%, 30%, and 60% (w/w) AmPcZn were successfully obtained. The chemical structure of the synthesized AmPcZn was confirmed by 1H-NMR spectroscopy and elemental analysis, which were consistent with the expected molecular composition. The grafting reaction and structural integrity of the resulting copolymers were investigated using Fourier-transform infrared (FTIR) and UV-Vis spectroscopies. FTIR spectra revealed characteristic amide and carbonyl stretching bands, confirming covalent bond formation between chitosan and AmPcZn. UV-Vis measurements showed a concentration-dependent increase in absorbance and a typical splitting of the Q-band with band at 605 nm and 715 nm, indicating the successful incorporation of the phthalocyanine moiety into the polymeric matrix.Item Spectroscopic properties of ZnPc(COOH)4/Ch/Fe3O4 supramolecular architectures [Articol](CEP USM, 2024) Druță, Alexandrina; Lungu, Ion; Popușoi, Ana; Potlog, Tamara; Bulmaga, Petru; Rusnac, RomanThis paper presents the synthesis of ZnPc(COOH)4/Ch/Fe3O4 supramolecular architectures at various ZnPc(COOH)4 and Ch/Fe3O4 concentrations explored in the synthesis process. Ch/Fe3O4 composite was prepared by a simple solution mixing-evaporation method. The validation of the synthesis was achieved through FTIR analysis and UV-Vis spectroscopy. FTIR of composite indicated an interaction between chitosan and Fe3O4 NPs. The chemical interaction of ZnPc(COOH)4 with Ch/F3O4 composite is confirmed by the shift of the signal from ν(C=O)) of protonated COOH groups in the FTIR spectrum of ZnPc(COOH)4, associated with spitting, to (νsym(COO)) and (νasym(COO)) that correspond to deprotonated carboxylic group. The absorption spectra of ZnPc(COOH)₄ revealed IR Q band with two subbands situated at 640 nm 700 nm. Also, the effect of various ZnPc(COOH) and Ch/Fe3O4 concentrations on absorbance of ZnPc(COOH)4/Ch/Fe3O4 supramolecular architecture is discussed.Item Polimeri analogi din copolimeri de N-vinilpirolidonă grefat cu ftalocianină de zinc [Articol](CEP USM, 2023) Robu, Ștefan; Potlog, Tamara; Lungu, Ion; Bulmaga, Petru; Tiulenau, Pavel; Prisacari, Viorel; Sava, VeronicaÎn lucrare este descrisă sinteza polimerilor analogi din N-vinilpirolidonă cu clorură de acriloil funcționalizați cu ftalocianină de zinc utilizând metoda Friedel-Crafts. Grefarea ftalocianinei de zinc la copolimerul de N-vinilpirolidonă s-a realizat la temperaturi joase (3-5 ⁰C), cu utilizarea catalizatorului AlCl3 anhidru. Purificarea polimerilor noi s-a realizat prin precipitarea în apă. Analiza structurii chimice a polimer analogilor s-a realizat prin utilizarea spectroscopiei IR și UV/Vis. A fost evaluată activitatea antimicrobiană, in vitro, a copolimerilor grefați cu ftalocianină de zinc față de tulpinile microbiene ca S. Aureus, E. Coli, Ps. Aeruginosa și altele. S-a demonstrat că polimer analogii obținuți posedă activitate bactericidă relativ înaltă față de culturile Ps. Aeruginosa, Pr. Vulgaris în comparație cu furacilina sau clorhexidina, utilizate în calitate de substanțe de referință.Item Sinteza și cercetarea ftalocianinelor de Zn substituite cu grupări nitro și amino [Articol](CEP USM, 2022-11-10) Popuşoi, Ana; Lungu, Ion; Rusnac, Roman; Bulmaga, Petru; Robu, Ştefan; Potlog, TamaraItem Sisteme polimerice din metaloftalocianină de zinc cu chitosan pentru terapia fotodinamică [Articol](CEP USM, 2021) Bulimestru, Ion; Popa, Nelea; Tiuleanu, Pavel; Lungu, Ion; Potlog, Tamara; Robu, Ștefan