Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology

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Author: search.filters.author.Graur, VasiliiSubject: search.filters.subject.biological activity

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    SYNTHESIS AND BIOLOGICAL ACTIVITY OF COPPER(II), NICKEL(II) AND COBALT(III) COORDINATION COMPOUNDS WITH 2-BENZOYLPYRIDINE N(4)-ALLYL-SMETHYLISOTHIOSEMICARBAZONE
    (2018) Usataia, Irina; Graur, Vasilii; Zariciuc, Elena; Garbuz, Olga; Gulea, Aurelian
    The paper presents the synthesis of the 2-benzoylpyridine N(4)-allyl-S-methylisothiosemicarbazone and five coordination compounds of copper(II), nickel(II) and cobalt(III) with this ligand. New synthesized substances were studied using IR and NMR (1H and 13C) spectroscopies, elemental analysis, molar conductivity and magnetochemical research. It was studied in vitro antimicrobial and antifungal activities against a wide range of standard strains Staphylococcus aureus (ATCC 25923), Escherihia coli (ATCC 25922), Klebsiella pneumonae and Candida albicans for synthesized substances. The study of the antiproliferative properties in vitro of the pro-ligand and complexes was tested on the human myeloid leukemia HL-60 and cervical cancer HeLa cells..
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    SYNTHESIS, STRUCTURE AND BIOLOGICAL ACTIVITY OF N(4)-ALLYL-3-THIOSEMICARBAZONES AND THEIR COORDINATION COMPOUNDS WITH SOME 3D METALS
    (CEP USM, 2015) Graur, Vasilii
    The paper presents a review of different N(4)-allyl-3-thiosemicarbazones and their coordination compounds described in literature. N(4)-allyl-3-thiosemicarbazide can form corresponding thiosemicarbazones with aliphatic, aromatic and heteroaromatic carbonyl compounds. In the presence of transitional metal ions they can form coordination compounds of different structures. Both coordination compounds and proligands manifest antitumor, antibacterial, antiviral, and antimalarial activities. Copper(II) coordination compounds with these ligands manifest better antitumor activity than corresponding proligands.
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    SYNTHESIS AND BIOLOGICAL ACTIVITY OF NICKEL AND COPPER COORDINATION COMPOUNDS OF 5-NITROFURAN-2-CARBALDEHYDE N(4)-ALLYL-3-THIOSEMICARBAZONE
    (CEP USM, 2014) Graur, Vasilii; Zariciuc, Elena; Tsapkov, Victor; Barba, Nina; Gulea, Aurelian
    The paper presents the synthesis of the ligand 5-nitrofuran-2-carbaldehyde N(4)-allyl-3-thiosemicarbazone (HL) and eight coordination compounds of copper(II) and nickel(II) with this ligand. The structure of thiosemicarbazone HL was studied using 1 H and 13С NMR spectroscopy. For the synthesized compounds their antimicrobial and antifungal activity was studied on a series of standard strains. For HL and Cu(HL)2(NO3)2 the antitumor activity towards human leukemia HL-60 cells was estimated. It was established that coordination compounds manifest better activity than free ligand.