Facultatea de Chimie şi Tehnologie Chimică / Faculty of Chemistry and Chemical Technology

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    SYNTHESIS , CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF COPPER( II), NICKEL(II), COBALT(III) AND IRON(III) CO ORDINATION COMPOUNDS WITH 1 - (2 - HYDROXYPHENYL)ETHANONE N(4) - ALLYL - S - METHYLISOTHIOSEMICARBAZONE
    (CEP USM, 2018) Usataia, Irina
    The paper presents the synthesis of the 1-(2-hydroxyphenyl)ethanone N(4)-allyl-S-methylisothiosemicarbazone (HL) and seven coordination compounds of copper , nickel , cobalt and iron with this pro - ligand. The new ly obtained compounds were inves tigated by IR, 1 H and 13 C NMR spectroscopy, elemental analysis, molar electric conductibility and magnetic susceptibility. For the synthesized compounds the antibacterial and antifungal activities in vitro were studied on a series of standard strains, such as Staphylococcus aureus (ATCC 25923), Escherihia coli (ATCC 25922), Klebsiella pneumonae and Candida albicans . The in vitro antiproliferative a ctivity of the pro - ligand and complexes was screened on Hep - 2, BxPC - 3, RD cancer cells and normal MDCK cells . I t was established that coordination compounds manifest better antiproliferative activity than the proligand.