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NEW INORGANIC AND ORGANIC MOLECULAR INHIBITORS OF CANCER CELLS PROLIFERATION, THE MECHANISMS OF ACTION
(2021) Garbuz, Olga
The theoretical importance and potential application value of the work. New inhibitors of cancer cell proliferation with high selective activity and low toxicity have been identified which made it possible to propose them for preclinical studies. A method for determination of the dependence of toxicity on the concentration of substances using Paramecium cadatum has been developed. The use of this method allows to accelerate and reduce the cost of biotesting. The mechanism of the action of the antiproliferative activity of the tested compounds has been found to associate with apoptosis. NMR spectroscopy and X-ray diffraction analyses have demonstrated that thiosemicarbazones interact with the DNA fragment (guanine), forming hydrogen bonds, which causes DNA fragmentation and finally apoptosis. The findings are of scientific significance and can be used for special training courses in Biopharmaceutical Chemistry and Biochemistry.